This paper developed an Alzheimer's disease rat model carrying abnormal Savda syndrome and studied its behavioral changes. First of all, an abnormal Savda syndrome rat model was developed by using the classical method then β-Amyloid 1-40 was injected into hippocampus to establish Alzheimer's disease in these rats. After observing the biological characteristics and testing behavioral changes with Morris water maze test and step down test, the abilities of learning and memorizing of different model groups were compared. Compared with the normal group, the daily food and water intake was increased in the abnormal Savda syndrome group and the AD group (P<0.01), the body weigh was decreased in the abnormal Savda syndrome group, the AD group and the AD carrying abnormal Savda syndrome group (P<0.01). The numbers of crossing the effective area were reduced in the abnormal Savda syndrome group, the AD group and the AD carrying abnormal Savda syndrome group (P<0.01) with respect to the normal group. The number of crossing the effective area was smaller in the AD carrying abnormal Savda syndrome group (P<0.05) than that in the AD group. The learning and memory scores were significantly lower in the abnormal savda syndrome group, the AD group and the AD carrying abnormal Savda syndrome group (P<0.01) than those in the normal group. Compared with the AD group, the learning and memory scores slightly lowered in the AD carrying abnormal Savda syndrome group without any significant statistical difference(P > 0.05). In this research, the Alzheimer's disease carrying abnormal Savda syndrome rat model was developed successfully.

Alzheimer's disease  /  abnormal Savda syndrome  /  animal models