The title compound of 5-(4-fluorophenyl)-11-(4-methoxy benoyl)-2,3,4,5-tetrahydro-1H-indolo[2,3-b]quinolin-1-one has been synthesized by the reaction of simple and off-the-shalf 3-p-methoxyphenacylideneoxindole with 3-(4-fluorophenylamino) cyclohex-2-enone as raw material in the presence of EtONa in ethanol. The structure of title product is determined by single crystal X-ray diffraction. The crystal is monoclinic, space group Cc, with Mr=537.57 (containing a molecular DMF solvent), a=1.44352(3) nm, b=2.6027(3) nm, c=0.93423(8) nm, V=2.6917(4) nm³, Z=4, D_c=1.327 Mg/m³, μ=0.093 mm^-1, F(000)=1128. The structure is solved by direct methods and refined by full-matrix least squares method to the final R=0.0631, R_ω=0.1535. X-ray analysis reveals that the formation of the new nitrogen-bearing six-member heterocyclic ring in the crystal structure is a coplanar structure.

Domino reaction  /  indolo[2,3-b]quinoline  /  crystal structure