To examine the association between adverse childhood experiences(ACEs) and the 10‑year frailty development trajectories in Chinese middle‑aged and older adults,so as to provide evidence for life‑course‑oriented healthy ageing promotion strategies.

Using data from the China Health and Retirement Longitudinal Study(CHARLS) spanning 2011-2020,we identified frailty development trajectories through group‑based trajectory modelling,and applied multinomial Logistic regression to analyse the relationship between ACEs and these trajectories.

A total of 10 032 middle‑aged and older adults were included.The baseline frailty index was 0.14±0.09,and 78.86% of the respondents reported at least one ACE.Three frailty trajectories were identified in the Chinese sample:stable non‑frailty(65.9%),critical turning point(23.9%),and progressive frailty(10.1%).Multinomial Logistic regression showed that ACEs were significantly associated with frailty trajectories(P<0.05),and a higher number of ACEs was associated with a higher relative risk of belonging to more severe frailty trajectory groups(P<0.05).

ACEs are associated with the 10‑year frailty development trajectories in Chinese middle‑aged and older adults,suggesting that childhood adversity may be an important distal risk factor for the long‑term evolution of frailty in later life.This highlights the need for early prevention from a life‑course perspective and precise intervention in old age.

To investigate the preferences of community residents in Suzhou for "Internet+nursing" services using a discrete choice experiment,and to provide a reference for enhancing service uptake and establishing a scientific service delivery model.

A discrete choice experiment was conducted via a questionnaire survey among 522 residents from three administrative districts in Suzhou. A mixed Logit model was employed using Stata 15.0 to quantify preference coefficients for service attributes,and to calculate willingness-to-pay and relative importance.

Residents in Suzhou preferred service plans characterized by lower out-of-pocket costs,one-day advance appointment scheduling,nurses with over 10 years of work experience,shorter service duration,and service provision by community health centers,public secondary hospitals,or public tertiary hospitals(P<0.05).The impact of changes in different attributes on choice probability varied.

Nursing cost,the type of healthcare institution providing the service,nurses' years of experience,and appointment waiting time are key attributes influencing residents' choices.Service attributes of "Internet+nursing" should be optimized based on the preference characteristics of Suzhou residents,with a focus on enhancing the supply of services from public healthcare institutions and senior nurses to align with resident needs and improve service utilization.

To explore the trajectory of psychological stress changes and its influencing factors in nurses as second victims following adverse nursing events,aiming to provide references for healthcare institutions and managers to accurately identify key intervention populations and to develop more targeted support strategies.

A purposive sampling method was used to select 178 nurses who had experienced adverse nursing events from three tertiary first-class hospitals in Shandong province.Surveys were conducted using a general information questionnaire,the Perceived Stress Scale,the Second Victim Experience and Support Scale,and the Connor-Davidson Resilience Scale at four time points:upon reporting the adverse event(T1),and at 1 month(T2),2 months (T3),and 3 months (T4) post-event.Latent class growth modeling was employed to identify latent categories of psychological stress change trajectories.The Logistic regression analysis was used to examine influencing factors.

The psychological stress change trajectories of nurse second victims were classified into three categories:moderate-level slow-decline group(51.7%),high-level rapid-decline group(16.3%),and low-level slow-decline group(32.0%).Logistic regression analysis revealed that department type,whether the adverse event involved a verification error,nurse resilience,and second victim experience and support were significant influencing factors for the trajectory of psychological stress change(all P<0.05).

The psychological stress changes in nurse second victims exhibit three distinct trajectories,indicating population heterogeneity.Targeted interventions can be developed based on the group characteristics and influencing factors of these stress change trajectories,enabling nurses to receive effective psychological and emotional support following adverse events.

To investigate the effects of different body positions on hyphema,comfort,sleep quality,visual acuity,intraocular pressure,and the incidence of postoperative ocular adverse reactions in patients following primary open-angle glaucoma surgery.

A total of 159 postoperative patients with primary open-angle glaucoma hospitalized in the department of ophthalmology,the People's Hospital of Guangxi Zhuang Autonomous Region from September 2023 to December 2024 were enrolled.They were randomly divided into three groups using a random number table:experimental group 1(30° semi-recumbent position),experimental group 2(45° semi-recumbent position),and control group(60° semi-recumbent position),with 53 cases in each group.Hyphema,comfort,sleep quality,visual acuity,intraocular pressure,and incidence of postoperative ocular adverse reactions were compared among the three groups before intervention,24 hours post-intervention,and 48 hours post-intervention.

A total of 154 patients completed the intervention,including 52 in experimental group 1,51 in experimental group 2,and 51 in the control group.After 24 hours intervention,the Kolcaba Comfort Scale scores in experimental groups 1 and 2 were higher than that in the control group(P<0.05).The sleep quality score in experimental group 1 was lower than those in experimental group 2 and the control group(P<0.05).The incidence of postoperative adverse reactions in experimental group 1 was lower than that in experimental group 2 and the control group(P<0.05).No statistically significant differences were observed in terms of hyphema scores,visual acuity,or intraocular pressure among the three groups(P>0.05).

All three body positions facilitate hyphema absorption.However,the 30° and 45° semi-recumbent positions are superior to the 60° semi-recumbent position in improving patient comfort.Furthermore,the 30° semi-recumbent position not only effectively promotes hyphema absorption but also improves sleep quality and reduces the incidence of postoperative adverse reactions,providing evidence-based support for clinical nursing staff in decision-making of body position.

To identify the latent classes of physical activity barriers in pre-pregnancy overweight/obese women during gestation and to examine the relationship between these classes and sleep self-efficacy.

A total of 356 pre-pregnancy overweight/obese women attending obstetric clinics at a tertiary hospital in Shanxi Province from October 2024 to June 2025 were enrolled.Data were collected using a general information questionnaire,the Physical Activity Barriers Scale for Pregnant Women,and the Sleep Self-Efficacy Scale.Latent profile analysis was performed to classify physical activity barriers.Multinomial logistic regression was used to identify influencing factors for each class,and linear regression was applied to examine the effect of different classes on sleep self-efficacy.

Three latent classes of physical activity barriers were identified:low barriers(25.3%),moderate barriers(41.3%),and high barriers(33.4%).Multinomial Logistic regression showed that education level,gestational week,history of falls during pregnancy,and exercise habits significantly influenced class membership(P<0.05).Linear regression indicated that,after adjusting for confounders,the latent class of physical activity barriers was a significant predictor of sleep self-efficacy(P<0.05).

Physical activity barriers in pre-pregnancy overweight/obese women exhibit population heterogeneity.And they are closely associated with sleep self-efficacy.Comprehensive assessment of these barriers is warranted to develop targeted nursing interventions aimed at improving sleep self-efficacy in this population.

To investigate the dynamic histopathological evolution of catheter-related thrombosis(CRT) in rabbit marginal ear veins within 12-96 hours,and identify the critical time point for the initiation of thrombus organization.

Fifty New Zealand rabbits were divided into five indwelling groups with catheter retention durations of 12 h,24 h,48 h,72 h and 96 h(8 rabbits per group,with an additional 2 puncture-only control rabbits for each group).Semi-quantitative scoring was performed to evaluate thrombus characteristics,inflammatory response and vascular injury after hematoxylin-eosin(HE) staining.

The incidence of CRT rose from 25.0% at 12 h to 100.0% at 96 h(P<0.001).Scores for thrombus area,composition and adhesion stability increased significantly over time(all P<0.05).The dominant inflammatory cell shifted from neutrophils to macrophages,and vascular injury progressed from endothelial denudation to elastic lamina rupture.The total thrombus score was positively correlated with the total inflammatory score(r=0.89,P<0.001).

The pathological progression of CRT in rabbit marginal ear veins is time-dependent.The 48-hour time point may serve as a critical turning point for early thrombus organization and aggravated vascular injury,providing experimental histopathological evidence for determining the safe indwelling duration of peripheral intravenous catheters in clinical practice.

To assess the collaboration willingness and practices of clinical and nursing students during their internships and to analyze key influencing factors.

A total of 135 clinical medicine students and 143 nursing students interning at three tertiary first-class hospitals in Shanxi Province were recruited.Surveys were conducted using a demographic questionnaire,the Jefferson Scale of Attitudes Toward Physician-Nurse Collaboration,and a Physician-Nurse Collaboration Behavior Scale.

The total score of collaboration attitude among clinical medicine students was(50.97±5.47),while that of nursing students was(50.08±6.98),with no statistically significant difference between the two groups(P>0.05).The total score of physician-nurse collaboration behavior among clinical medicine students was (104.58±18.31),while that of nursing students was (95.53±22.00),There was a statistically significant difference between the two groups(P<0.05).Regression analysis revealed that professional identity and prior completion of interprofessional collaboration courses positively influenced collaboration attitude.Key factors affecting collaboration practices included joint case discussions with supervisors,internship stress,and professional identity.

Interns in medicine and nursing generally exhibit positive and convergent collaboration willingness,yet significant disparities in power perception and divergence in collaborative behaviors are evident.A dual-drive strategy combining "educational empowerment" and "structural empowerment" is recommended to enhance physician‑nurse collaboration competencies.

To evaluate the bidirectional causal relationship between emotional swing and colorectal cancer using Mendelian randomization,and to test the causal regulatory effect of emotional swing on lipid metabolism.

Using summary data from genome-wide association studies,we selected genetic variants associated with emotional swing, colorectal cancer,total cholesterol,and triglycerides as instrumental variables.A bidirectional Mendelian randomization design was applied to assess causal associations in both directions between emotional swing and colorectal cancer.The inverse variance weighted method served as the primary analysis,supplemented by weighted median and MR-Egger regression for sensitivity analysis.We also tested the individual effects of total cholesterol and triglycerides as potential mediators.

Forward causal analysis detected only a marginal negative association between emotional swing and colorectal cancer using inverse variance weighting(OR=0.981),suggesting insufficient robustness.Reverse causal analysis found no significant causal effect of colorectal cancer on emotional swing(OR=0.839).Further analysis revealed that emotional swing exerted opposite causal effects on the two lipid indicators:a negative causal relationship with total cholesterol(OR=0.688) and a positive causal relationship with triglycerides(OR=1.797),with stable results.

There is no robust bidirectional causal relationship between emotional swing and colorectal cancer,but emotional swing participates in disease progression through differential regulation of total cholesterol and triglycerides.Given the potential value of medicinal and edible resources of Shanxi in intervening in the emotion-metabolism-cancer axis,we recommend incorporating lipid metabolism indicators into comprehensive colorectal cancer risk management and exploring pathways for industrializing non‑nutrient components in community prevention and treatment.

To explore the latent profiles of undergraduate nursing students' perceptions of engaging in elderly care work and the influencing factors,and to provide references for improving elderly nursing education models.

From January to April 2025,599 undergraduate nursing students from six universities in Henan province were selected as the survey subjects.A general information questionnaire,the Nursing Students' Perceptions of Engaging in Elderly Care Work Scale, and the Attitudes Toward the Elderly Scale were used for the survey.Latent profile analysis was employed to identify the latent profiles of undergraduate nursing students' perceptions of engaging in elderly care work.Logistic regression analysis was used to explore the influencing factors.

Undergraduate nursing students' perceptions of engaging in elderly care work fell into three latent profiles:low cognition-expectation type (62%),moderate cognition-expectation type(24%),and high cognition-expectation type(14%).Logistic regression analysis showed that whether nursing was the first choice in the college entrance examination,whether living with elderly individuals,experience in caring for the elderly,optimism about the development prospects of the elderly care industry,and attitudes toward the elderly were influencing factors of the latent profiles of undergraduate nursing students' perceptions of engaging in elderly care work(P<0.05).

The low cognition-expectation type is the main profile among nursing students' perceptions of elderly care work.It suggests educators need to focus on comprehensive reform in geriatric nursing education.Reforms should address the nature of work,social recognition,interest, and career prospects.The goal is to enhance students' professional understanding and willingness to work in this field.

To explore the latent profiles of post-traumatic stress disorder(PTSD) in women undergoing involuntary termination of pregnancy,to analyze the characteristics of women in different profiles,and to investigate the related influencing factors.

From January to April 2025,205 women who underwent involuntary pregnancy loss and hospitalized in the tertiary grade A hospital in Changsha were selected as survey subjects.The General Information Questionnaire,the PTSD Symptom Scale-Self Report,and the Perceived Partner Responsiveness Scale were used for data collection.Latent profile analysis was conducted on PTSD symptoms.The univariate analysis and logistic regression analysis were employed to identify the influencing factors of these latent profiles.

PTSD in women undergoing involuntary pregnancy loss was classified into three profiles:low symptom-adaptive type(57.6%),moderate symptom type(31.2%),and high symptom-cognitive-emotional dysregulation type(11.2%).Logistic regression analysis showed that education level,average monthly family income,occupation,history of involuntary pregnancy loss,conception method,regularity of prenatal check-ups,and perceived partner responsiveness were influencing factors for the latent profiles of PTSD in these women(all P<0.05).

Heterogeneity exists in the PTSD symptoms among women undergoing involuntary pregnancy loss.Healthcare professionals should implement targeted nursing interventions based on the characteristics of patients in different profiles to improve their mental health.