Full
Outline
To translate the M.D.Anderson Symptom Inventory-chimeric antigen receptor T cell therapy module(MDASI-CAR) into Chinese and test its reliability and validity.
Following the Brislin translation model,the original scale underwent translation,cultural adaptation,and a preliminary survey to form the Chinese version of the MDASI-CAR.A total of 148 patients with hematological diseases who underwent CAR-T cell therapy in a tertiary hospital in Tianjin city were selected as study subjects by a convenience sampling method from January to August 2025.The reliability and validity of scale was analyzed.
The Chinese version of the MDASI-CAR consisted of 28 items.Exploratory factor analysis results showed that the 22 symptom assessment items extracted 6 common factors,with a cumulative variance contribution rate of 66.617%.The factor loadings for each item ranged from 0.402 to 0.887.The 6 symptom interference assessment items extracted 2 common factors,with a cumulative variance contribution rate of 71.706%.The factor loadings ranging from 0.742 to 0.905.The item-level content validity index ranged from 0.833 to 1.000.The scale-level average content validity index was 0.945.The scale scores correlated with those of the validity instrument(all P<0.001).The overall Cronbach's α coefficient for the scale was 0.930.
The Chinese version of the MDASI-CAR demonstrated good reliability and validity.It could be used to assess symptom severity and life interference in patients following CAR-T cell therapy.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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