Full
Outline
To systematically evaluate the genetic causal relationship between dietary preferences and allergic asthma using Mendelian randomization(MR).
Based on the genome-wide association study(GWAS) data of 187 dietary preferences from the UK Biobank,and the GWAS data of allergic asthma from the FinnGen database,a dual-sample Mendelian randomization analysis was conducted to explore the causal relationship.
The Mendelian randomization causal analysis showed that preferences for bacon,soft cheese,and cornflakes were positively associated with the risk of allergic asthma,while the preference for high-fiber vegetables showed protective effect against allergic asthma.The robustness of the results was verified through heterogeneity tests and level pleiotropy analysis.The leave-one-out sensitivity analysis results indicated that there was no dominant effect of a single-nucleotide polymorphism.
Preference for bacon,soft cheese,and cornflakes may increase the risk of allergic asthma,while preference for high-fiber vegetables may have protective effect.The research results provide preliminary genetic causal evidence for formulating dietary intervention-based prevention and control strategies for allergic asthma.
18
7
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62662699(Operation and Technical Support)
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
