Full
Outline
To explore the dynamic change characteristics of the incidence of hospital infections before and after the intervention of antimicrobial stewardship measures,and to quantitatively evaluate the short-term and long-term impacts of antimicrobial stewardship measures.
Data on the infection rate of Klebsiella pneumoniae(KPN) among inpatients from July 2017 to December 2018 were collected as pre-intervention data.Data on the KPN infection rate among inpatients from January 2019 to June 2020 were collected as post-intervention data.The Bayesian interrupted time series method was used to evaluate the changing trend of KPN infection rate before and after the implementation of antimicrobial stewardship measures.
The average monthly KPN infection rate from July 2017 to June 2020 was 0.941%.The average monthly KPN infection rate before the implementation of antimicrobial stewardship measures was 0.947%.The average monthly KPN infection rate after the implementation of antimicrobial stewardship measures was 0.934%.The parameter estimation results of the model with a lag period of 2 months showed that was statistically significant(P<0.05),with a risk ratio of 0.818. was statistically significant(P<0.05),=0.021,with a risk ratio of 1.021. was statistically significant(P<0.05),with a risk ratio of 1.661.The results of the relative changes between the predictive values and counterfactual values showed that the changes from March to May 2019 all decreased (all P<0.05),while the changes from April to June 2020 all increased (all P<0.05).
The Bayesian interrupted time series model could effectively evaluate the short-term and long-term effects of intervention measures.It could also evaluate whether the intervention had a lag effect or not.The implementation of hospital antimicrobial stewardship measures could reduce the infection risk in the short term,with a 2-month lag period in the intervention effect,while the long-term effect was not ideal.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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