Objective To develop a virtual simulation teaching program for individual nutritional intervention in hospitalized patients and to evaluate its application effectiveness. Methods A total of 169 nursing undergraduate students from a university of grade 2022 were selected as research group.A virtual simulation experiment teaching of nutritional intervention for hospitalized patients was conducted in the course of clinical nutrition.A total of 196 nursing undergraduate students of grade 2021 were selected as control group,which were received regular teaching.The teaching effect was evaluated after the teaching activity completed. Results The school platform recorded a cumulative of 1 028 accesses with 78 hours of usage time.Per⁃user login attempts ranged from 2 to 9 times,while the practical training score averaged 95.42±10.37 points.Student satisfaction rating reached full marks(10/10).The provincial platform served 760 distinct users with 35 cumulative usage hours.Individual login frequencies spanned 1 to 5 attempts,yielding a training score of 91.33±12.68 points.User evaluation also achieved a perfect 10⁃point score.The stage test scores of the nursing undergraduate students in research group(30.17±4.12) were significantly higher than that of the nursing undergraduate students in control group(26.96±3.33).There was a statistically significant difference between them(P<0.001).A total of 77.30%⁃5.89% of nursing undergraduates acknowledged that the virtual simulation teaching program facilitates learning engagement,enhances self⁃directed learning capabilities,and cultivates the learning mindset.Through virtual simulation training,82.21%-91.41% of students achieved mastery of core nutritional competencies including risk screening,assessment,intervention,and monitoring.The overwhelming majority expressed satisfaction with the system's functional design,reporting consistently positive learning experiences. Conclusions The virtual simulation experiment teaching could effectively improve the academic performance of nursing undergraduate students and enhance the quality of clinical nutrition teaching.