Full
Outline
To investigate the medication adherence trajectory during the intensive phase in patients with drug-resistant tuberculosis(DR-TB) and to analyze its influencing factors.
Patients with DR-TB treated at the Public Health Clinical Center of Chengdu city from March to December 2024 were selected as the study subjects by a convenience sampling method.Medication adherence was assessed using the Morisky Medication Adherence Scale(MMAS-8) at the beginning of treatment,3 months of treatment,and 6 months of treatment.The latent class growth model(LCGM) was used to analyze medication adherence trajectories.Multivariate Logistic regression analysis was used to explore the influencing factors of different trajectories.
A total of 179 patients with DR-TB completed follow-up.Their MMAS-8 scores at the beginning of treatment,3 months of treatment,and 6 months of treatment were 6.07±1.72,5.92±1.75,and 6.01±1.69,respectively.There were no statistically significant differences across the three time points(P>0.05).Two medication adherence trajectories were identified among patients with DR-TB,namely the improving medication adherence group(56.425%) and the declining medication adherence group(43.575%).Logistic regression analysis showed that average monthly income,place of residence,educational level,category of systemic adverse reactions,presence of other chronic diseases,self-efficacy,social support,and self-management ability were influencing factors for the medication adherence trajectory during the intensive phase in patients with DR-TB(all P<0.05).
Medication adherence during the intensive phase in patients with DR-TB was at a moderate level and exhibited population heterogeneity.Healthcare providers should pay attention to patients with declining medication adherence and develop personalized nursing measures based on the influencing factors to improve patient medication adherence.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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