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Bidirectional two-sample Mendelian randomization study of causal relationships between mental disorders, insomnia, and irritable bowel syndrome
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Zhean HE, Chaoqun DONG, Yingying HUANG, Jing LIN, Xiaoyi LU, Xinnan MAO, Shimeng DAI, Hailu SONG, Mengli XU, Sisi JIANG
Chinese Nursing Research | 2026, 40(6) : 881 - 893
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Chinese Nursing Research | 2026, 40(6): 881-893
• Original Articles •
Bidirectional two-sample Mendelian randomization study of causal relationships between mental disorders, insomnia, and irritable bowel syndrome
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Zhean HE, Chaoqun DONG, Yingying HUANG, Jing LIN, Xiaoyi LU, Xinnan MAO, Shimeng DAI, Hailu SONG, Mengli XU, Sisi JIANG
Affiliations
  • 1School of Nursing, Wenzhou Medical University, Zhejiang 325035 China
Published: 2026-03-25 doi: 10.12102/j.issn.1009-6493.2026.06.001
Outline
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Objective

To analyze the causal relationships between mental disorders,insomnia,and irritable bowel syndrome(IBS) using a bidirectional two-sample Mendelian randomization(MR) approach.

Methods

The primary analysis was conducted using the random-effects inverse variance weighted(IVW) method on genome-wide association study summary data.Heterogeneity was assessed using Cochran's Q statistic.The horizontal pleiotropy was tested using the intercept from MR-Egger regression.

Results

Forward MR analysis revealed that major depressive disorder,schizophrenia,and insomnia were positively associated with the increased risk of IBS(all P<0.05).Reverse MR analysis indicated that IBS was positively associated with the increased risk of major depressive disorder and insomnia (all P<0.05).Cochran's Q test in the forward MR analysis showed heterogeneity in the causal estimates for the genetic instruments of schizophrenia,insomnia,and bipolar disorder,while no heterogeneity was observed for other outcomes.MR-Egger regression indicated no significant horizontal pleiotropy for any of the results(P>0.05).

Conclusion

Major depressive disorder,schizophrenia, and insomnia have causal associations with IBS.

mental disorders  /  insomnia  /  irritable bowel syndrome  /  Mendelian randomization  /  causal relationship
何哲安, 董超群, 黄莹莹, 林静, 陆晓毅, 毛欣楠, 戴诗梦, 宋海璐, 徐梦莉, 江思思. 精神疾病及失眠与肠易激综合征间的双向双样本孟德尔随机化因果关系研究. 护理研究, 2026 , 40 (6) : 881 -893 . DOI: 10.12102/j.issn.1009-6493.2026.06.001
Zhean HE, Chaoqun DONG, Yingying HUANG, Jing LIN, Xiaoyi LU, Xinnan MAO, Shimeng DAI, Hailu SONG, Mengli XU, Sisi JIANG. Bidirectional two-sample Mendelian randomization study of causal relationships between mental disorders, insomnia, and irritable bowel syndrome[J]. Chinese Nursing Research, 2026 , 40 (6) : 881 -893 . DOI: 10.12102/j.issn.1009-6493.2026.06.001
Appendix
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Year 2026 volume 40 Issue 6
40
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Article Info
doi: 10.12102/j.issn.1009-6493.2026.06.001
  • Receive Date：2025-02-22
  • Online Date：2026-10-28
  • Published：2026-03-25
Article Data
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History
  • Received：2025-02-22
  • Revised：2025-12-24
Affiliations
    1School of Nursing, Wenzhou Medical University, Zhejiang 325035 China

Corresponding:

JIANG Sisi, E-mail:
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