To explore the clinical efficacy of Sijun Wendan Formula combined with Febuxostat tablets in the treatment of gouty nephropathy and its impact on patients' renal function.

A total of 148 patients with gout nephropathy admitted to the Department of Nephrology and Rheumatology of Anqing First People's Hospital (from January 2023 to January 2025) were included in this study. The patients were evenly divided into two groups by the random number table method. Patients in the control group (74 cases) were treated with febuxostat tablets. Patients in the observation group (74 cases) were treated with Febuxostat Tablets + Sijun Wendan Formula. During the study, 3 cases dropped out in the control group and 2 cases in the observation group. Eventually, there were 72 cases in the observation group and 71 cases in the control group. Observe the therapeutic effects of the two groups of patients, the TCM syndrome scores before and after treatment (such as frequent nocturia, low back pain, joint swelling and pain, etc.), procalcitonin (PCT), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), serum uric acid (UA), blood urea nitrogen (BUN), serum creatinine (Scr), glomerular filtration rate (eGFR), and the level of 24-hour urine protein quantification (24h UTP) and adverse reactions.

The curative effect of observation group was higher than that of control group(P < 0.05); After treatment, TCM symptom scores (nocturnal frequent urination, lumbago, joint swelling pain, etc.), PCT, CRP, ESR, UA, BUN, Scr, 24h UTP levels were decreased in both groups (P < 0.05), and eGFR levels were increased(P < 0.05). After treatment, the TCM syndrome scores (nocturnal frequent urination, lumbago, joint swelling pain, etc.), PCT, CRP, ESR, UA, BUN, Scr, 24h UTP levels in observation group were lower than those in control group(P < 0.01), and eGFR levels were higher than those in control group(P < 0.05); The incidence of adverse reactions in observation group was lower than that in control group (P <0.01).

The combination of Sijun Wendan Formula and Febuxostat tablets has a good clinical effect in the treatment of gouty nephropathy, and can effectively improve patients' symptoms and renal function. The treatment is safe and reliable.