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Outline
The microbiota-gut-brain axis（MGBA）plays an important role in the pathogenesis and treatment of post-stroke depression（PSD）.The gut microbiota，as a key regulatory factor of this pathway，participates in the onset of PSD through neural，endocrine，metabolic，and immune systems，and maintains bidirectional communication between the brain and the gut.Research indicates that traditional Chinese medicine（TCM）can act on the MGBA through multiple pathways.Single herbs such as Chaihu（Bupleurum），Roucongrong（Cistanches Herba）and Ciwujia（Acanthopanax root）can regulate the gut microbiota，inhibit inflammation，and modulate the HPA axis. Compound formulas，such as Xiaoyao Powder and Chaigui Granule，can increase short-chain fatty acids，regulate amino acid metabolism，and collaboratively restore neurotransmitter and neurotrophic factor levels.Animal experiments have confirmed that TCM monomers and compound preparations can regulate the overall function of the gut microbiota. Combined with dietary interventions and gut microbiota transplantation，they can regulate the proportion of beneficial and harmful bacteria，restoring microbial structure and metabolic balance.In the future，it is necessary to explore how traditional Chinese medicine can target the gut microbiota and transform its active components to exert biological effects，promote multidisciplinary and multi-target research，clarify the pathogenesis of PSD，enhance fecal microbiota transplantation and Chinese medicine-microbiota co-culture techniques，and systematically validate the value of the MGBA in individualized and precise treatment of PSD by integrating animal experiments with clinical practice.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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