Home Journals Articles Updates About
CN
image
收藏切换
Expert consensus on liquid biopsy-based multi-cancer early detection (2025 edition)
收藏切换
PDF
Wanqing Chen1, Kexin Chen2, Yutong He3, Weihua Jia4, Zhihua Liu1, Hongxia Ma5, Xiaoping Miao6, Kaifeng Pan7, Chen Wu1, Changfa Xia1, Jinliang Xing8, Yongjie Xu1, Working Group for the Development of Expert Consensus on Liquid Biopsy-based Multi-Cancer Early Detection
Chinese Journal of Clinical Oncology | 2025, 52(14) : 727 - 742
Less
收藏切换
Chinese Journal of Clinical Oncology | 2025, 52(14): 727-742
• Guidelines and Consensus •
Expert consensus on liquid biopsy-based multi-cancer early detection (2025 edition)
Full
Wanqing Chen1, Kexin Chen2, Yutong He3, Weihua Jia4, Zhihua Liu1, Hongxia Ma5, Xiaoping Miao6, Kaifeng Pan7, Chen Wu1, Changfa Xia1, Jinliang Xing8, Yongjie Xu1, Working Group for the Development of Expert Consensus on Liquid Biopsy-based Multi-Cancer Early Detection
Affiliations
  • 1Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021,China
  • 2Department of Epidemiology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
  • 3Office of Cancer Prevention, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
  • 4State Key Laboratory of Oncology in South China, Guangdong Provincial Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510050, China
  • 5Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China
  • 6Department of Epidemiology and Biostatistics, School of Public Health, Wuhan University, Wuhan 430071, China
  • 7Department of Epidemiology, Peking University Cancer Hospital & Beijing Institute for Cancer Prevention and Research, State Key Laboratory of Gastrointestinal Cancer Precision Prevention and Integration Therapy, Beijing Key Laboratory of Carcinogenesis and Translational Research, Beijing 100142, China
  • 8Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Air Force Medical University, Xi'an 710032, China
Published: 2025-07-30 doi: 10.12354/j.issn.1000-8179.2025.20250754
Outline
收藏切换

Cancer stands as a significant global public health challenge, and cancer screening serves as a pivotal strategy for reducing its mortality. Presently, only a limited number of cancer types have appropriate screening methods available. Traditional single-cancer screening approaches are fraught with limitations, including invasiveness, low accuracy, and poor patient compliance. Multi-cancer early detection (MCED) leveraging liquid biopsy technology enables non-invasive and efficient early detection of multiple cancers by analyzing biomarkers such as cell-free DNA, cell-free RNA, proteins, and metabolites in blood and other bodily fluids. This innovative approach substantially broadens the spectrum of detectable cancers and enhances population coverage, showcasing immense potential for improving existing cancer screening strategies. This expert consensus comprehensively reviews the progress of liquid biopsy-based MCED, biomarker selection and detection technologies, the criteria for cancer type selection,research design and clinical utility evaluation, as well as implementation pathways. The overarching goal of this consensus is to offer scientific guidance for further research and the widespread adoption of MCED, thereby facilitating the continuous optimization of cancer screening strategies.

neoplasms  /  liquid biopsy  /  multi-cancer early detection  /  tumor biomarkers  /  expert consensus
Wanqing Chen, Kexin Chen, Yutong He, Weihua Jia, Zhihua Liu, Hongxia Ma, Xiaoping Miao, Kaifeng Pan, Chen Wu, Changfa Xia, Jinliang Xing, Yongjie Xu, Working Group for the Development of Expert Consensus on Liquid Biopsy-based Multi-Cancer Early Detection. Expert consensus on liquid biopsy-based multi-cancer early detection (2025 edition)[J]. Chinese Journal of Clinical Oncology, 2025 , 52 (14) : 727 -742 . DOI: 10.12354/j.issn.1000-8179.2025.20250754
Appendix
Less
Year 2025 volume 52 Issue 14
PDF
183
85
Cite this Article
BibTeX
Article Info
doi: 10.12354/j.issn.1000-8179.2025.20250754
  • Receive Date：2025-06-05
  • Online Date：2026-04-09
  • Published：2025-07-30
Article Data
Affiliations
History
  • Received：2025-06-05
  • Revised：2025-06-23
Affiliations
    1Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021,China
    2Department of Epidemiology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
    3Office of Cancer Prevention, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
    4State Key Laboratory of Oncology in South China, Guangdong Provincial Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510050, China
    5Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China
    6Department of Epidemiology and Biostatistics, School of Public Health, Wuhan University, Wuhan 430071, China
    7Department of Epidemiology, Peking University Cancer Hospital & Beijing Institute for Cancer Prevention and Research, State Key Laboratory of Gastrointestinal Cancer Precision Prevention and Integration Therapy, Beijing Key Laboratory of Carcinogenesis and Translational Research, Beijing 100142, China
    8Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Air Force Medical University, Xi'an 710032, China

Corresponding:

Wanqing Cheng; E-mail:
References
Share
https://castjournals.cast.org.cn/joweb/zgzllc/EN/10.12354/j.issn.1000-8179.2025.20250754
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House