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To establish an animal model of polycystic ovary syndrome (PCOS) characterized by kidney deficiency and blood stasis, and to evaluate its efficacy.
SD rats were randomly divided into normal group, PCOS group, model group and formula counter-evidence group, with 10 rats in each group. The normal group was given 1 mg·kg-1 1% sodium carboxymethyl cellulose daily by intragastric administration; PCOS group was given 1 mg·kg-1 letrozole daily by intragastric administration; on the basis of PCOS group, the model group was injected subcutaneously with 0.6 mg·kg-1 epinephrine hydrochloride solution daily for 2 weeks from day 21. On the basis of the model group, the formula counter-evidence group was given 12.51 g·kg-1 Zhu’s Tiaojing decoction daily for 2 weeks from the 21st day. After 35 days of intervention, the indexes of ovarian index, testosterone, vitamin D and whole blood low shear rate were compared.
The ovarian indexes of normal, PCOS, model and formula counter-evidence groups were (6.39±0.58)×10-4, (5.32±0.71)×10-4, (5.05±0.29)×10-4 and (8.17±0.65)×10-4; testosterone concentrations were (7.10±0.97), (9.22±0.43), (9.06±1.21) and (7.73±0.76) nmol·L-1; vitamin D levels were (1 850.98±227.95), (986.10±152.50), (1 220.67±64.35) and (1 598.20±294.75) pg·mL-1; whole blood low shear rates were (13.00±1.79), (13.37±0.54), (16.38±1.51) and (11.43±2.77) mPa·s, respectively. The above indexes in the model group were statistically significant compared with the formula counter-evidence group and the normal group (all P<0.05).
Letrozole combined with epinephrine hydrochloride can stably replicate the PCOS rat model with kidney deficiency and blood stasis syndrome.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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