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Acute lung injury (ALI) is a severe respiratory disease. Given the limited existing treatment methods, it is urgent to explore new therapies. Pyroptosis plays a crucial role in the onset of ALI. Traditional Chinese medicine can regulate the pathways related to pyroptosis, reduce the inflammatory response, and improve acute lung injury, thus providing new strategies for the treatment of ALI. This article systematically reviews the mechanisms by which pyroptosis causes ALI in alveolar macrophages, neutrophils, and pulmonary vascular endothelial cells, summarizes the published literature from 2019 to 2024, and explores the action mechanisms of active ingredients and compound prescriptions of traditional Chinese medicine in the treatment of ALI, aiming to provide a theoretical basis for the research and development of new drugs.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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