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Protective effect of Yinxing Mihuan oral solution on acute myocardial ischemia injury in rats
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Hao GUO1, Jian-xun REN1, Ting-ting HAO1, Cheng-ren LIN1, Jian-xun LIU1, *, Yi-min WANG2, Yong WANG2, Yue SHI1, Yan-lei MA1
Acta Pharmaceutica Sinica | 2017, 52(12) : 1865 - 1870
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Acta Pharmaceutica Sinica | 2017, 52(12): 1865-1870
• ORIGINAL ARTICLES •
Protective effect of Yinxing Mihuan oral solution on acute myocardial ischemia injury in rats
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Hao GUO1, Jian-xun REN1, Ting-ting HAO1, Cheng-ren LIN1, Jian-xun LIU1, *, Yi-min WANG2, Yong WANG2, Yue SHI1, Yan-lei MA1
Affiliations
  • 1. Beijing Key Laboratory of Chinese Materia Pharmacology, Institute of Basic Medical Sciences of Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China
  • 2. Xi'an Buchang Traditional Chinese Cardio-cerebrovascular Disease Hospital, Xi'an 710082, China
Published: 2017-12-15 doi: 10.16438/j.0513-4870.2017-0598
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This study was designed to investigate the effect of Yinxing Mihuan oral solution on rats with myocardial ischemia injury. Left anterior descending (LAD) coronary artery was occluded in rats to establish the model. Yinxing Mihuan oral solution was given by intragastric administration daily for one week at dosage of 309 and 618 mg·kg-1. Cardiac ultrasound function, pathologic change and serum myocardial enzymes were determined to evaluate the effect of Yinxing Mihuan oral solution. The heart function was significantly reduced in the model group compared with sham operation group, and the pathologic damage was clear. The changes were significantly improved by Diltiazem hydrochloride tablets in heart function and ejection fraction (P < 0.01). The ejection fraction and stroke volume was improved by Yinxing Mihuan oral solution (618 mg·kg-1) (P < 0.05, P < 0.01). In addition, Yinxing Mihuan oral solution decreased the myocardial damage and inhibited inflammatory reaction, and inhibited platelet activation factor. Yinxing Mihuan oral solution can protect against myocardial ischemia injury, inflammation and platelet activation in the rat model.

myocardial ischemia  /  cardiac function  /  Yinxing Mihuan oral solution  /  inflammatory factor  /  platelet activation factor
Hao GUO, Jian-xun REN, Ting-ting HAO, Cheng-ren LIN, Jian-xun LIU, Yi-min WANG, Yong WANG, Yue SHI, Yan-lei MA. Protective effect of Yinxing Mihuan oral solution on acute myocardial ischemia injury in rats[J]. Acta Pharmaceutica Sinica, 2017 , 52 (12) : 1865 -1870 . DOI: 10.16438/j.0513-4870.2017-0598
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Year 2017 volume 52 Issue 12
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Article Info
doi: 10.16438/j.0513-4870.2017-0598
  • Receive Date：2017-06-22
  • Online Date：2026-01-14
  • Published：2017-12-15
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History
  • Received：2017-06-22
  • Revised：2017-07-17
Funding
Affiliations
    1. Beijing Key Laboratory of Chinese Materia Pharmacology, Institute of Basic Medical Sciences of Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China
    2. Xi'an Buchang Traditional Chinese Cardio-cerebrovascular Disease Hospital, Xi'an 710082, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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