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A new dimeric benzylisoquinoline alkaloid from Corydalis yanhusuo
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Gui-yang XIA1, Biao-bing XIAO2, Ling-yan WANG2, Dong-jie FANG2, Huan XIA1, Sheng LIN*, 1
Acta Pharmaceutica Sinica | 2021, 56(2) : 553 - 556
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Acta Pharmaceutica Sinica | 2021, 56(2): 553-556
• Original Articles •
A new dimeric benzylisoquinoline alkaloid from Corydalis yanhusuo
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Gui-yang XIA1, Biao-bing XIAO2, Ling-yan WANG2, Dong-jie FANG2, Huan XIA1, Sheng LIN*, 1
Affiliations
  • 1. Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
  • 2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2021-02-12 doi: 10.16438/j.0513-4870.2020-1564
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(±)-Bicoryanhunine B(1), a new dimeric benzylisoquinoline alkaloid was isolated from the dried tubers of Corydalis yanhusuo by various chromatographic methods, including silica gel, Sephadex LH-20, reverse phase C18, and semi-preparative HPLC.Its structure was determined by spectroscopic methods, including UV, IR, ESI-MS, HR-ESI-MS and 1D/2D NMR.(±)-Bicoryanhunine B(1) was a moderate PD-1/PD-L1 interaction inhibitor with an IC50 value of 7.80±0.49 μmol·L-1.In addition, 1 exhibited potent inhibitory activities against LPS-induced NO production in RAW 264.7 macrophages with an IC50 value of 4.83 ± 2.21 μmol·L-1.

Corydalis yanhusuo  /  dimeric alkaloid  /  PD-1/PD-L1  /  anti-inflammatory
Gui-yang XIA, Biao-bing XIAO, Ling-yan WANG, Dong-jie FANG, Huan XIA, Sheng LIN. A new dimeric benzylisoquinoline alkaloid from Corydalis yanhusuo[J]. Acta Pharmaceutica Sinica, 2021 , 56 (2) : 553 -556 . DOI: 10.16438/j.0513-4870.2020-1564
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Article Info
doi: 10.16438/j.0513-4870.2020-1564
  • Receive Date：2020-09-29
  • Online Date：2025-12-18
  • Published：2021-02-12
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  • Received：2020-09-29
  • Revised：2020-10-29
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Affiliations
    1. Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
    2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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