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Research progress of polymer self-healing mechanism and its application in biomedicine
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Jin-yue WANG1, 2, Jin-wei DI2, Li-xun LÜ1, Ai-ping ZHENG2, Lin-lin ZHAO1, *, Jing GAO2, *
Acta Pharmaceutica Sinica | 2023, 58(1) : 86 - 94
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Acta Pharmaceutica Sinica | 2023, 58(1): 86-94
• Reviews •
Research progress of polymer self-healing mechanism and its application in biomedicine
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Jin-yue WANG1, 2, Jin-wei DI2, Li-xun LÜ1, Ai-ping ZHENG2, Lin-lin ZHAO1, *, Jing GAO2, *
Affiliations
  • 1. North China University of Science and Technology, Tangshan 063210, China
  • 2. Institute of Pharmacology and Toxicology, Academy of Military Sciences, Academy of Military Sciences, Beijing 100850, China
Published: 2023-01-12 doi: 10.16438/j.0513-4870.2022-0564
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Polymer self-healing is mainly based on the molecular structure and interaction of polymers, and some need external stimulation, such as light, heat, pH, etc. In recent years, many studies have found that the self-healing properties of polymers can prolong the life of materials, while maintaining the mechanical properties of polymers after healing. According to the different action modes of polymer materials, it can be divided into autonomous self-healing and non-autonomous self-healing. Among them, autonomous self-healing mainly works through reversible covalent bonds (Schiff base bond, Diels-Alder reaction, hydrazide bond), reversible non-covalent bonds (hydrogen bond, metal-ligand coordination bond, electrostatic interaction, π-π stacking interaction, hydrophobic interaction) and a combination of the two interactions. Drug carriers with unique self-healing properties play an important role in the encapsulation and stable release of biomacromolecules. In this review, the self-healing mechanism of polymers and their applications in the field of biomedicine were briefly summarized and discussed.

self-healing  /  covalent bond  /  non-covalent bond  /  drug-delivery  /  tissue-engineering
Jin-yue WANG, Jin-wei DI, Li-xun LÜ, Ai-ping ZHENG, Lin-lin ZHAO, Jing GAO. Research progress of polymer self-healing mechanism and its application in biomedicine[J]. Acta Pharmaceutica Sinica, 2023 , 58 (1) : 86 -94 . DOI: 10.16438/j.0513-4870.2022-0564
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Year 2023 volume 58 Issue 1
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Article Info
doi: 10.16438/j.0513-4870.2022-0564
  • Receive Date：2022-05-10
  • Online Date：2025-11-21
  • Published：2023-01-12
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  • Received：2022-05-10
  • Revised：2022-06-21
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Affiliations
    1. North China University of Science and Technology, Tangshan 063210, China
    2. Institute of Pharmacology and Toxicology, Academy of Military Sciences, Academy of Military Sciences, Beijing 100850, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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