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A new furan α-butenolactones from Alisma orientale and their potential antifibrotic activities
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Deng-hui ZHU1, 2, Peng-li GUO1, 2, Si-qi TAO1, 2, Jing-ke ZHANG1, 2, Meng-nan ZENG1, 2, Xiao-ke ZHENG1, 2, 3, Wei-sheng FENG1, 2, 3, *
Acta Pharmaceutica Sinica | 2024, 59(7) : 2058 - 2061
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Acta Pharmaceutica Sinica | 2024, 59(7): 2058-2061
• Original Articles •
A new furan α-butenolactones from Alisma orientale and their potential antifibrotic activities
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Deng-hui ZHU1, 2, Peng-li GUO1, 2, Si-qi TAO1, 2, Jing-ke ZHANG1, 2, Meng-nan ZENG1, 2, Xiao-ke ZHENG1, 2, 3, Wei-sheng FENG1, 2, 3, *
Affiliations
  • 1. College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
  • 2. Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
  • 3. Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan Province and Ministry of Education of China, Zhengzhou 450046, China
Published: 2024-07-12 doi: 10.16438/j.0513-4870.2023-1368
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Four furan α-butenolactones were isolated from 50% acetone extract of tuber of Alisma orientale by silica gel column, chromatography gel column and high performance liquid chromatography techniques. Their structures were identified by modern wave spectroscopy techniques and electronic circular dichroism (ECD) and assigned as (5R)-5-hydroxy-3, 4-dimethylfuran-2(5H)-one (1), 5-hydroxy-3, 5-dimethylfuran-2(5H)-one (2), 5-hydroxy-4-(1-methylethyl)-2(5H)-furanone (3) and alismanoid A (4). Compound 1 was new compound and compounds 2–4 were first isolated from Alisma orientale. Compound 1-4 had potential antifibrotic activities.

Alisma orientale  /  furan α-butenolactone  /  structure identification  /  antifibrotic
Deng-hui ZHU, Peng-li GUO, Si-qi TAO, Jing-ke ZHANG, Meng-nan ZENG, Xiao-ke ZHENG, Wei-sheng FENG. A new furan α-butenolactones from Alisma orientale and their potential antifibrotic activities[J]. Acta Pharmaceutica Sinica, 2024 , 59 (7) : 2058 -2061 . DOI: 10.16438/j.0513-4870.2023-1368
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doi: 10.16438/j.0513-4870.2023-1368
  • Receive Date：2023-12-06
  • Online Date：2025-11-26
  • Published：2024-07-12
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  • Received：2023-12-06
  • Revised：2024-02-19
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Affiliations
    1. College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
    2. Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
    3. Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan Province and Ministry of Education of China, Zhengzhou 450046, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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