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Advances in understanding leukemia bone marrow microenvironments
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Zhao-na YANG1, Feng WANG1, 2, Ting-ting ZHANG2, Ping-ping LI1, Ke LI2, *, Bing CUI1, *
Acta Pharmaceutica Sinica | 2022, 57(9) : 2601 - 2611
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Acta Pharmaceutica Sinica | 2022, 57(9): 2601-2611
• Special Reports: Therapeutic interventions and strategies for cancer immunotherapy •
Advances in understanding leukemia bone marrow microenvironments
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Zhao-na YANG1, Feng WANG1, 2, Ting-ting ZHANG2, Ping-ping LI1, Ke LI2, *, Bing CUI1, *
Affiliations
  • 1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, CAMS Key Laboratory of Molecular Mechanism and Target Discovery of Metabolic Disorder and Tumorigenesis, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2022-09-12 doi: 10.16438/j.0513-4870.2021-1524
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The bone marrow microenvironment, also known as the bone marrow niche, plays a critical role in maintaining the functions of hematopoietic stem cells. Under physiological conditions, various bone marrow cells regulate each other to sustain hematopoietic homeostasis. However, bone marrow cells gain abnormal function under pathological conditions to cause and promote the occurrence of leukemia and induce drug resistance. Recent findings indicate that abnormal proliferation and differentiation are not the sole reason to cause leukemia. Different types of bone marrow cells also induce intercellular adhesion, abnormally secrete cytokines and chemokines, accelerating leukemia's progress. This article reviews the multiple signaling pathways that regulate the formation and progress of leukemia bone marrow niche, such as C-X-C motif chemokine ligand 12/C-X-C motif chemokine receptor 4 signaling pathway, et al. It emphasizes that targeting leukemia bone marrow niche is a vital strategy for improving the leukemia treatment.

bone marrow microenvironment  /  leukemia  /  drug resistance  /  bone marrow niche  /  immune microenvironment  /  cancer stem cell
Zhao-na YANG, Feng WANG, Ting-ting ZHANG, Ping-ping LI, Ke LI, Bing CUI. Advances in understanding leukemia bone marrow microenvironments[J]. Acta Pharmaceutica Sinica, 2022 , 57 (9) : 2601 -2611 . DOI: 10.16438/j.0513-4870.2021-1524
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Article Info
doi: 10.16438/j.0513-4870.2021-1524
  • Receive Date：2021-10-22
  • Online Date：2025-12-24
  • Published：2022-09-12
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History
  • Received：2021-10-22
  • Revised：2021-12-27
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Affiliations
    1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, CAMS Key Laboratory of Molecular Mechanism and Target Discovery of Metabolic Disorder and Tumorigenesis, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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