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A new lignan from Gleditsiae spina
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Chen HE1, 2, Yan-gang CAO1, 2, Man QI1, 2, Bei-bei ZHANG1, 2, Ying-jie REN1, 2, Yan-ling LIU1, 2, Meng-na WANG1, 2, Xiao-ke ZHENG1, 2, Wei-sheng FENG1, 2, *
Acta Pharmaceutica Sinica | 2020, 55(12) : 2951 - 2954
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Acta Pharmaceutica Sinica | 2020, 55(12): 2951-2954
• Original Articles •
A new lignan from Gleditsiae spina
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Chen HE1, 2, Yan-gang CAO1, 2, Man QI1, 2, Bei-bei ZHANG1, 2, Ying-jie REN1, 2, Yan-ling LIU1, 2, Meng-na WANG1, 2, Xiao-ke ZHENG1, 2, Wei-sheng FENG1, 2, *
Affiliations
  • 1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
  • 2. The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou 450046, China
Published: 2020-12-12 doi: 10.16438/j.0513-4870.2020-1241
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The chemical constituents from ethyl acetate extract of Gleditsiae spina were isolated and purified by various chromatographic methods such as MCI gel CHP-20, ODS, Sephadex LH-20, silica gel and semi-preparative HPLC. Seven lignans were isolated and identified by spectroscopic data analyses as (7R, 8S, 7'E, 7''S, 8''R)-buddlenol P (1), (+)-syringaresinol (2), (+)-isolariciresinol (3), (7S, 8R)-cedrusin (4), (7S, 8R)-4, 9, 9'-trihydroxy-3, 3'-dimethoxy-7, 8-dihydrobenzofuran-1'-propylneolignan (5), 3', 4-O-dimethylcedrusin (6), balanophonin (7). Among them, compound 1 is a new lignan, compounds 2-7 are isolated from the Gleditsia L. for the first time. MTT method was used to investigate the effect of compounds 2-7 on LPS-induced injury of NRK-52e cells. As a result, compounds 2, 3 and 7 exhibit protective effects against LPS-induced damage to NRK-52e cells.

Gleditsia L.  /  Gleditsiae spina  /  lignans  /  (7R, 8S, 7'E, 7''S, 8''R)-buddlenol P
Chen HE, Yan-gang CAO, Man QI, Bei-bei ZHANG, Ying-jie REN, Yan-ling LIU, Meng-na WANG, Xiao-ke ZHENG, Wei-sheng FENG. A new lignan from Gleditsiae spina[J]. Acta Pharmaceutica Sinica, 2020 , 55 (12) : 2951 -2954 . DOI: 10.16438/j.0513-4870.2020-1241
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Year 2020 volume 55 Issue 12
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Article Info
doi: 10.16438/j.0513-4870.2020-1241
  • Receive Date：2020-07-27
  • Online Date：2026-01-23
  • Published：2020-12-12
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History
  • Received：2020-07-27
  • Revised：2020-10-21
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Affiliations
    1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
    2. The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou 450046, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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