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Ideas and strategies for investigating the bioactive constituents of animal derived traditional Chinese medicines based on integrated "proteomics/peptidomics-modifications" methods
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Rui LIU1, 2, 3, Ming ZHAO1, 3, Jin-ao DUAN1, 3, *
Acta Pharmaceutica Sinica | 2020, 55(8) : 1735 - 1743
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Acta Pharmaceutica Sinica | 2020, 55(8): 1735-1743
• Reviews •
Ideas and strategies for investigating the bioactive constituents of animal derived traditional Chinese medicines based on integrated "proteomics/peptidomics-modifications" methods
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Rui LIU1, 2, 3, Ming ZHAO1, 3, Jin-ao DUAN1, 3, *
Affiliations
  • 1. National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine and Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China
  • 2. Jiangsu Key Laboratory of Research and Development in Marine Bio-resource Pharmaceutics, Nanjing University of Chinese Medicine, Nanjing 210023, China
  • 3. School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
Published: 2020-08-12 doi: 10.16438/j.0513-4870.2019-1035
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Animal derived traditional Chinese medicines (ATCMs) are an important part of traditional Chinese medicine (TCM). The lack of proper ideas and strategies made it not systematic and perfect enough on investigating bioactive components and quality evaluation of ATCMs, which restrict many aspects of ATCMs investigation including clinical applications, pharmaceutical technologies, and quality control. Therefore, based on our previous investigations of animal horn and animal derived gelatin TCMs, and the research progress at home and abroad, ideas and strategies for investigating the correlations between proteins/peptides and their bioactivities in animal horn and animal gelatin derived TCMs based on integrated "proteomics/peptidomics-modifications" methods was proposed. Firstly, proteomics and peptidomics analysis can be used to study proteins and peptides in ATCMs. Secondly, modification analysis can be used to reveal those chemical modifications on proteins and peptides of ATCMs. Thirdly, the correlations between components, modifications and traditional bioactivities can be systemic discussed. Based on the present study, hopefully, enough evidences and reference can be provided to resolve the issues in ATCMs investigations on modernization and bioactive material basis.

horn  /  gelatin  /  animal derived traditional Chinese medicine  /  proteomes  /  peptidomes  /  modification
Rui LIU, Ming ZHAO, Jin-ao DUAN. Ideas and strategies for investigating the bioactive constituents of animal derived traditional Chinese medicines based on integrated "proteomics/peptidomics-modifications" methods[J]. Acta Pharmaceutica Sinica, 2020 , 55 (8) : 1735 -1743 . DOI: 10.16438/j.0513-4870.2019-1035
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doi: 10.16438/j.0513-4870.2019-1035
  • Receive Date：2019-12-23
  • Online Date：2026-01-21
  • Published：2020-08-12
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History
  • Received：2019-12-23
  • Accepted：2020-01-09
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Affiliations
    1. National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine and Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China
    2. Jiangsu Key Laboratory of Research and Development in Marine Bio-resource Pharmaceutics, Nanjing University of Chinese Medicine, Nanjing 210023, China
    3. School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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