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Research progress on anti-depression effects of ginsenosides
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Si-yu REN1, 2, Zhen-zhen WANG2, Nai-hong CHEN1, 2, *
Acta Pharmaceutica Sinica | 2019, 54(12) : 2204 - 2208
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Acta Pharmaceutica Sinica | 2019, 54(12): 2204-2208
• Reviews •
Research progress on anti-depression effects of ginsenosides
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Si-yu REN1, 2, Zhen-zhen WANG2, Nai-hong CHEN1, 2, *
Affiliations
  • 1. College of Pharmacy, Hunan University of Chinese Medicine, Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, Changsha 410208, China
  • 2. Institute of Materia Medica, Neuroscience Center, Chinese Academy of Medical Sciences, Beijing 100050, China
Published: 2019-12-12 doi: 10.16438/j.0513-4870.2019-0264
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Ginseng is a traditional Chinese medicine known as the "king of herbs" since ancient time in China. It was found in animal experiments that total saponins, ginsenoside monomers or glycosides from ginseng extraction all showed antidepressant effects in chronic unpredictable stress, corticosterone or lipopolysaccharide induced depression models. Taking ginsenosides as the focus, we reviewed the antidepressive mechanisms from the perspectives of various hypotheses, such as regulations of hypothalamic-pituitary-adrenal axis, monoamine neurotransmitter and neuroplasticity related to the pathogenesis of depression. The mechanism, target and pharmacodynamic targets of ginsenosides for anti-depression were summarized, in order to provide references for multi-targets and multi-level development of new anti-depression drugs, and improvement of diagnosis and treatment of depression from the perspective of traditional Chinese medicine and natural products.

ginseng  /  depression  /  ginsenoside  /  ginsenoside Rg1  /  antidepressive mechanism
Si-yu REN, Zhen-zhen WANG, Nai-hong CHEN. Research progress on anti-depression effects of ginsenosides[J]. Acta Pharmaceutica Sinica, 2019 , 54 (12) : 2204 -2208 . DOI: 10.16438/j.0513-4870.2019-0264
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Year 2019 volume 54 Issue 12
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Article Info
doi: 10.16438/j.0513-4870.2019-0264
  • Receive Date：2019-04-11
  • Online Date：2026-01-26
  • Published：2019-12-12
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  • Received：2019-04-11
  • Revised：2019-05-07
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Affiliations
    1. College of Pharmacy, Hunan University of Chinese Medicine, Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, Changsha 410208, China
    2. Institute of Materia Medica, Neuroscience Center, Chinese Academy of Medical Sciences, Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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