Objective To establish a high performance liquidchromatography method for the determination of the content uniformity ofpromethazine hydrochloride, and to provide a reliable experimental basisfor the subsequent study of the content uniformity and content qualityof pediatric drugs after manual breaking tablets. Methods Highperformance liquid chromatography was used, octadecyl silane bondedsilica gel was used as the column filling agent, water (adjusted pH to2.3 with glacial acetic acid)-methanol (55 : 45) was used as the mobilephase, and the detection wavelength was ${254}\mathrm{\;{nm}}$ . ResultsPromethazine hydrochloride showed a good linear relationship in therange of 17.392~26.088 μg/mL, and the linear equation was: $\mathrm{Y}= {55272}\mathrm{X}+{348938}\left({{r}^{2}= {0.9986}}\right)$ . The method recoveryrate was between 100.22% and 101.40%, and the RSD was ${0.49}\%$ . The content uniformity ofpromethazine hydrochloride was in accordance with the provisions of thefour general principles of the Chinese Pharmacopoeia 2020 edition.Finally, this method was used to analyze the accuracy of children’sdrugs by different methods of dosing by the content and contentuniformity of promethazine hydrochloride tablets. Conclusion The method has strong specificity in determining the content uniformity and content of promethazine hydrochloride, and the accuracy and precision are good. The dose accuracy of children’s tablets is reduced by many times of dosing, and it also provides very important data theoretical and practical significance for promoting the dose accuracy of children’s tablets.

With the gradual depletion of natural sand resources, the replacement of natural sand by machine-made sand is an inevitable trend, and the performance of machine-made sand has a certain impact on the workability, mechanics and durability of concrete. In 2023, Zhenjiang Construction Engineering Quality Inspection Association carried out the comparison of machine-made sand laboratories, analyzed the testing ability level of each laboratory and identified the problems existing in the laboratory, and carried out technical analysis on the factors affecting the detection results of machine-made sand methylene blue value, stone powder content and crushing index, and put forward relevant suggestions.

Objective To explore the determination of trace glutathioneby resonance scattering spectral quenching method and improve thesensitivity of the method. Methods In the pH 3.0 phosphoric acid-boricacid-acetic acid buffer solution (BR buffer), $\mathrm{{Fe}}\left(\mathrm{{III}}\right)$ reacts with ${\mathrm{K}}_{4}\left\lbrack {\mathrm{{Fe}}{\left(\mathrm{{CN}}\right)}_{6}}\right\rbrack$ to form Prussian blue ion associates, and the system exhibits a strongresonance scattering effect at ${337}\mathrm{\;{nm}}$ . When glutathione isadded, the sulfhydryl group in glutathione molecules can reduce Fe(III)to Fe(II), causing quenching of the system and weakening the resonancescattering quenching effect. Results The linear regression equation forglutathione within the concentration range of 0.010 to ${2.0\mu }\mathrm{g}/\mathrm{{mL}}$ is ${\Delta l}= {299.77\rho }+{774.52}$ , with an ${r}^{2}$ of 0.9929 and a detection limit of ${0.0024\mu }\mathrm{g}/\mathrm{{mL}}$ . Conclusion This method is simple and highly sensitive, and satisfactoryresults are obtained when used for the determination of glutathione indrugs.

Total sulfur in coal is one of the important indicators for evaluating coal quality. In order to effectively and economically utilize coal resources, it is necessary to comprehensively understand the total sulfur content in coal. Based on the principle of coulometric titration and the consideration of man-machine material loop measurement, this paper deeply explores the main factors affecting the measurement accuracy, aiming to significantly improve the accuracy of total sulfur determination through systematic analysis of the influence of various factors on the detection and standardization of the correct use, inspection and maintenance of the instrument.

Objective To establish a method for determining thecontents of paeoniflorin, cinnamaldehyde and paeonol in Guizhi JiliuPills. Methods The RP-HPLC wavelength switching method was used, theanalysis was achieved on an ES Epic ${\mathrm{C}}_{18}\left({{4.6}\mathrm{\;{mm}}\times {250}\mathrm{\;{mm}},{5\mu}\mathrm{m}}\right)$ column, the mobile phase was acetonitrile-0.1% aqueous solution of phosphoric acid gradient elution, the flowrate was ${1.0}\mathrm{\;{mL}}/\mathrm{{min}}$ , thecolumn temperature was ${25}^{\circ }\mathrm{C}$ and thedetection wavelength were ${230}\mathrm{\;{nm}}$ $\left({0\sim {25}\mathrm{\;{min}}}\right),{290}\mathrm{\;{nm}}\left({{25}\sim {41}\mathrm{\;{min}}}\right)$ and ${274}\mathrm{\;{nm}}\left({{41}\sim {51}\mathrm{\;{min}}}\right)$ . Results The linear ranges of paeoniflorin, cinnamaldehyde and paeonolwere 3.6169~90.4232 μg/mL ( $r={0.9993}$ ),1.8388~45.9695 μg/mL ( $r={0.9999}$ ),2.0240~50.5994 μg/mL ( $r={0.9999}$ ). The average sample recovery rates were95.4%(RSD=1.2%), 93.0%(RSD=0.7%) and 94.2%(RSD=1.2%) respectively. Conclusion This method is accurate, sensitive, and has strong specificity. It can be used for the quality control of Guizhi Jiliu Pills.

University laboratories are characterized by their complex functions, high safety risks, and significant management challenges. Establishing a sound safety education and training model is an important means to promote the safety management of laboratories. This study discusses the current issues in safety education and training for university laboratories, including the structural issue that safety education and training are not incorporated into the laboratory management system, the process issue of having a singular form of safety education and training and a lack of targeted content, and the result issue of the absence of an evaluation mechanism for safety education and training. In response to these issues, a university laboratory safety education and training model based on structure-process-result is constructed around pre-experiment, during-experiment, and post-experiment stages, providing references for improving the safety literacy of laboratory personnel and ensuring the safe operation of laboratories.

Objective To investigate the laboratory detectioncapability of the determination of hexachlorocyclohexane pesticideresidues in plant extract concentrates of various laboratories under thegroup. Methods Using plant extract concentrate as the substrate, $\beta$ -hexachlorocyclohexane and $\delta$ -hexachlorocyclohexane was used asthe target substance, and a comparison sample was prepared by adding amatrix. After uniformity and stability verification, robust statisticalalgorithm A was used to calculate the robust mean and robust standarddeviation. The laboratory detection ability of hexachlorocyclohexanepesticide residues in plant extract concentrate was evaluated based onthe $Z$ -ratio score. Results Theuniformity and stability test results of the comparison samples meet therequirements, and the satisfaction rate of the detection of pesticideresidues in plant extract concentrate is 100%. The participatinglaboratories have good detection capabilities. Conclusion Compared withproficiency testing, inter laboratory comparisons have the advantages oflow cost and convenient organization, making them an effectivesupplement to proficiency testing activities.

With the rapid development of medical education, medical laboratory plays a crucial role in cultivating medical talents and scientific research innovation. However, due to the complexity and specificity of laboratory management, traditional management methods are no longer able to meet the needs of modern laboratory management. This article aims to explore the application of standardized management measures in the management of medical school laboratories. Through in-depth analysis of the current situation of medical school laboratory management, a series of standardized management measures are proposed to improve the efficiency of laboratory management, ensure the safe and stable operation of laboratories, and provide strong guarantees for medical education and scientific research innovation.

As an important energy resource, the quality of coal directly affects combustion efficiency, environmental emissions, and product quality. Traditional detection methods rely on manual sampling and laboratory testing, which have issues such as uneven sampling, cumbersome operations, and long cycles, making it difficult to meet real-time and accurate requirements. This paper proposes optimization solutions including multimodal information fusion, standardization and automation, and intelligent monitoring systems. These technologies significantly improve the accuracy and efficiency of coal quality detection and have been validated in both laboratory and industrial applications, demonstrating their great potential in real-time monitoring and management of coal quality. The optimized methods not only more accurately reflect the actual ash and sulfur content in coal products but also provide strong technical support for the development of the coal industry, achieving intelligent and efficient coal quality monitoring.

Objective To explore the effectiveness of gas chromatography-mass spectrometry in detecting volatile organic compounds in soil. Methods Gas chromatography-mass spectrometry was used to detect 24 groups of soil samples from a certain factory. Results There are certain differences in the types and concentrations of VOCs in soil from different regions. The soil of this factory contains volatile organic compounds such as benzene series, chlorinated hydrocarbons, and esters, which meet the monitoring requirements for VOCs in soil. Conclusion Experimental results have shown that gas chromatography-mass spectrometry can accurately detect the types, components, and contents of volatile organic compounds in soil, with high accuracy in the detection results. It is worth promoting and applying.