Drug regulatory authorities in all countries have clear regulations and requirements on the production and quality control of drugs. High performance liquid chromatography (high performance liquid chromatography, HPLC), as one of the important means of drug quality control, is widely used in the development, production and circulation of drugs, to ensure that the quality of drugs complies with the relevant regulations and production specifications. This study analyzed the technical principle and characteristics of HPLC technology, summarized and summarized its application in drug quality analysis, further clarified the application effect and value of HPLC in drug quality analysis, and provided power for drug quality and safety management.

Objective To analyze the reasons for the appearance of special-shaped oil drop image in spot method, broaden the applicability of the spot method, and improve detection efficiency. Methods Ten typical samples with different combinations of facet, cabochon, polished, and frosted were tested by a gem refractometer. The study focused on abnormal oil drop images whichhas no clear boundary between light and dark areas but variations in light and dark areas, as well as the cases that the abnormal oil droplet image did not show changes in light and dark areas but only a small bright spot moving along with the oil droplet image. Results It was indicated that even when abnormal oil droplet images are observed in Spot method, reliable refractive index values of gemstones can still be rapidly obtained. Conclusion This study broadens the applicability of Spot method to obtain refractive index for faceted, fine frosted gemstone, and the determination of refractive indices beyond the range of the refractometer in three specific scenarios.

Objective A method to identify heavy metal outliers in soil of site environmental investigation was studied. Methods First, the normal distribution test of soil heavy metal samples was carried out, then the heavy metal outliers were identified by the PauTa criterion, and the frequency histogram was used to verify the outliers identification results. Results The results of the case study show that the PauTa criterion can effectively identify the outliers of heavy metal content in the soil of the site environmental investigation. Conclusion The use of PauTa criterion to identify the outliers of heavy metal content in soil of site environmental investigation is helpful to identify the soil that is lower than the screening value but greatly affected by human production and life, and can greatly reduce the risk of soil cumulative pollution.

Objective The microwave digestion procedure was not clearly described in the previous standard, which affected the systematic analysis of measurement factors. Methods The heavy metals in municipal sludge was determined by the microwave high-pressure digestion-ICP. A mathematical model for heavy metals measurement in the municipal sludge was established. Results The main sources of uncertainty come from ICP instrument, sample weighing and calibration curve fitting. Conclusion Countermeasures and suggestions for reducing the uncertainty were introduced, which may provided technical basis for improving the accuracy of heavy metals measurement.

With the increasing frequency of scientific research activities in universities, laboratory gas cylinders have both special equipment and hazardous chemicals, making their safe use and management particularly important. This article first analyzes the main problems in the current management of gas cylinders in university laboratories, and then proposes improvement measures from the perspective of gas cylinder users to strengthen safety education and training for gas cylinder users, develop and improve operating procedures for gas cylinder use, and standardize the safety inspection of gas cylinders; propose to audit supplier qualifications from the perspective of managers and standardize source management; carry out graded and classified supervision, and implement a regular inspection system; using information technology to improve management efficiency; intensify the promotion of safety culture and establish a management strategy for benchmark laboratories, aiming to improve the safety of laboratory gas cylinder use and provide reference for laboratory gas cylinder safety management.

Food and drug quality and safety are closely related to the production and life of the people, and food and drug testing institutions bear the important responsibility of food and drug quality and safety. As an important place for food and drug inspection institutions to carry out experimental testing work, chemical laboratories involve many chemical indicators in the process of food and drug random inspection and testing. Whether the chemical indicator parameters are qualified or not has a significant impact on the testing results. Therefore, strengthening the quality control of chemical laboratories in food and drug testing institutions is beneficial to improving the accuracy, timeliness, and effectiveness of experimental testing results. The current food and drug industry is developing rapidly, with various types of food and drugs appearing in society. Food and drug testing technology and methods are also becoming increasingly perfect. However, overall, the tasks undertaken by chemical laboratories are still relatively arduous, and the risks of operating chemical laboratories are relatively high. This article focuses on the analysis of the current situation of quality control in chemical laboratories of food and drug inspection institutions, and then conducts research on the key points of quality control in chemical laboratories for reference by peers in testing.

In the information age, laboratory management is facing new challenges and opportunities. The traditional laboratory management model can no longer fully meet the needs of the information age, so it is necessary to innovate and explore management concepts and practices. This article aims to explore innovative concepts and practical experiences in laboratory management in the information age. By introducing advanced information technology, promoting open innovation, emphasizing performance evaluation and quality management, and cultivating innovative talents, laboratory management can achieve better results and outcomes.

Objective To systematically control the quality of nucleic acid testing laboratories through the HACCP system, in order to improve the quality of nucleic acid testing laboratories and provide reference for effectively formulating quality control strategies for nucleic acid testing. Methods Preliminary exploration of quality control in nucleic acid testing laboratories based on the HACCP system, with a focus on analyzing the monitoring procedures, validation measures, and corrective measures developed by the HACCP system in the stages of nucleic acid sample reception, preparation of reagents, sample nucleic acid extraction, nucleic acid amplification, result interpretation, and nucleic acid testing result reporting. Results By analyzing the testing data December 2021 to December 2022, the results showed that all batches of nucleic acid positive quality control products met the judgment rules, and each batch of experiments was in a controlled state. Statistical analysis was conducted on laboratory data under the HACCP system, calculating their standard deviation, mean, and coefficient of variation. After plotting the box plot, outlier tests were conducted, and it was found that the mean did not produce outliers. Conclusion The application of HACCP system in nucleic acid testing laboratories can effectively control the quality of nucleic acid testing laboratories, comprehensively control important control points of nucleic acid testing laboratories, improve the level and quality of laboratory biosafety,

Hazardous waste from laboratories possesses dangerous characteristics such as toxicity, corrosiveness, flammability, infectiousness, and reactivity. Improper handling of such waste can pose threats to human health and the ecological environment. This article analyzes the problems existing in the management of laboratory hazardous waste and proposes targeted management points to help laboratories avoid potential risks, which is of great significance for the scientific management of laboratory hazardous waste.

In current technological research and laboratory testing, quality management is crucial to ensuring the reliability of test data, the accuracy of test results, and the repeatability of tests. In order to improve the quality management level of testing laboratories, various quality management system certifications such as CNAS (China National Accreditation Service for Conformity Assessment) and CMA (China Inspection Body and Laboratory Mandatory Approval) have been widely used in laboratories through certification and review processes. The laboratory extensively employs the PDCA cycle (Plan-Do-Check-Act) in quality management. This article explores the application of the PDCA cycle in quality management of testing laboratories and its benefits to laboratory quality management.