Scientific research and experimental teaching are the main functions of university laboratory. Therefore, university laboratory plays an important role in personnel training and scientific research and development. However, many kinds of chemicals are stored in university laboratories, and some of them have the characteristics of being flammable and explosive, which increases the risk of accidents in university laboratories and easily threatens the safety of students and teaching staff, therefore, colleges and universities should pay attention to the laboratory safety management and control work, timely detection of security risks, improve laboratory safety. This paper describes the current situation of laboratory management in colleges and universities, and puts forward some safety control measures to provide reference for laboratory management.

Objective In this paper, aiming at the shortcomings of the industry standard of GA/T 1522-2018 Forensic Science Shooting Residue Inspection Scanning Electron Microscopy/X-Ray Spectroscopy, which only provides a few reference characteristic forms and has limited reference such as no reference energy spectrum diagram. Through simulation experiments, a practical reference is provided for the inspection of shooting residues. Methods Taking the shooting of 7.62 mm Type 51 bullet with Type 54 pistol as an example, shooting experiments of naked and clothed human bodies were simulated, and the collection, preparation and inspection steps of shooting residues, typical morphology and composition characteristics of shooting residues were explained in detail. Results Through simulation experiments, the scanning electron microscope morphology and energy spectrum characteristics of the shooting residues produced by the Type 54 pistol shooting the 7.62 mm Type 51 bullet were obtained. Conclusion Each gun and bullet combination has its own specific SEM morphology and energy spectrum characteristics.

Objective To evaluate the uncertainty of determination oftotal cadmium (Cd), lead (Pb) and chromium (Cr) in soil by microwavedigestion and inductively coupled plasma mass spectrometry (ICP-MS).Methods To ensure the accuracy and reliability of the detection results,the uncertainty of total cadmium (Cd), lead (Pb) and chromium (Cr) insoil was determined by microwave digestion and inductively coupledplasma mass spectrometry (ICP-MS) and according to JJF1059.1-2012Evalution and Expression of Uncertainty in Measurement the syntheticuncertainty was calculated and the extended uncertainty was obtained.Results The main sources of uncertainty were the standard curvepreparation the repeatability measurement of samples and the standardcurve fitting the contribution rates to the uncertainty of $\mathrm{{Cd}},\mathrm{{Pb}}$ and Cr were50.4%~60.3%, 18.7%~26.1% and 12.1%~20.4%. The influence of sampleweighing and resolution volume for the uncertainty was small and thecontribution rate was between 1.5%~2%, which could be ignored.Conclusion The effective measures to control uncertainty were putforward, which ensured the reliability of the experimental data andprovided the reference for the accurate representation of the heavymetal content in soil

Objective Evaluation of ochratoxin A (OTA) contamination inGejie Dingchuan Pills. Methods Eighty-six samples from sevenpharmaceutical manufacturers were analyzed for OTA content usingultra-high-performance liquid chromatography-tandem mass spectrometry.Results The method displayed excellent linearity within the range ofconcentrations ${0.1}\sim {10}\mathrm{{ng}}/\mathrm{{mL}}$ .The limits of detection and quantification were ${0.2}\mathrm{{\mu g}}/\mathrm{{kg}}$ and $1\mathrm{{\mu g}}/\mathrm{{kg}}$ ,respectively. Seventy-two samples were detected to be contaminated withOTA, resulting in an 84% positive rate. Furthermore, ten samples failedto meet the required standards, reflecting a failure rate of 12%. Theactual sample test results showed that the OTA detection rate of GejieDingchuan pills was high and the pollution was serious, which suggestedthe urgency of detecting and determining the maximum OTA limit ofproprietary Chinese medicine. Conclusion This study assesses the extentof OTA contamination in Gejie Dingchuan pills, offering a scientificbasis for future investigations of OTA maximum limits in Chineseproprietary medicines.

Objective To improve the precision and accuracy of atomicfluorescence spectrometry for the determination of total seleniumcontent. Methods This article analyzes the factors affecting thedetermination of total selenium in geochemical samples by hydridegeneration atomic fluorescence spectrometry, and explores threeinfluencing factors: sample digestion, instrument cleanliness, andcoexisting ion interference. Optimized the sample digestion process,summarized the issues that should be noted in the instrument during thesample determination process, as well as the common methods foridentifying and eliminating coexisting ion interference. Results Thefeasibility of the method has been verified through 13 national firstlevel standard reference materials, the detection limit of the method is ${0.006}\mathrm{{mg}}/\mathrm{{kg}}$ ,which is lower than the detection limit of DZ/T 0279.14-2016 (0.01mg/kg). The relative standard deviation of the test standard substancewere ${1.9}\%\sim {7.9}\%$ , and $\left|{\Delta\mathrm{{lg}}C}\right|$ were all less than 0.1 . The precisionand accuracy meet the requirements of DZ/T0011-2015 Geochemical CensusSpecification (1:50000). Conclusion Effectively solved the problem ofunstable quality in the determination of total selenium by atomicfluorescence spectroscopy, and improved precision and accuracy.

Objective Collect peanuts and soybeans in Beijing throughvarious channels, determine the content of 26 metal elements among them.Methods The sample is pre-processed by using a microwave to eliminatethe sample, the content of 26 metal elements was determined by inductivecoupling plasma body constituent. Results The detection limit and linearrange of 26 elements can meet the detection requirements, thecorrelation coefficients are above 0.9980 or more, relative standarddeviation (RSD) in the range of 1.1% to 6.8%, the average recovery rateis within the range of 88.8% to 108.7%. In general the content of $\mathrm{K}$ , Ca, and $\mathrm{{Fe}}$ in soybeans far exceedspeanuts, Al in ordinary soybeans is significantly higher than organicsoybeans, the $\mathrm{{Fe}}$ of redpeanut peanuts is higher than white peanut peanuts. $\mathrm{{Pb}},\mathrm{{Cd}},\mathrm{{Cr}}$ with national standards of food safety have not exceeded the standard.Conclusion Through this method, it can be effectively used for themeasurement of 26 metal elements in peanuts and soybeans.

Objective To evaluate the early diagnosis and prognosis ofmultiple myeloma (MM) by gene sequencing technology. Methods 68 patientswith MM admitted from May 2020 to May 2024 were randomly divided intoobservation group (34 cases) and control group (34 cases). Patients inthe observation group received early diagnosis and prognosis assessmentrelated to gene sequencing, while those in the control group receivedtraditional diagnosis methods. Results In the early diagnosis accuracy,the number of correct and wrong diagnoses in the observation group was31 cases and 3 cases, respectively, and the diagnosis accuracy was91.2%. The number of correct and wrong diagnoses in control group was 23cases and 11 cases, respectively, the diagnostic accuracy was ${67.62}\%$ , and the observation group washigher $\left({P <{0.05}}\right)$ .In the observation group, the number of ISS stage I, ISS Stage II, ISSStage III and high-risk mutation detection were 10 cases, 15 cases, 9cases and 12 cases, respectively, and the accuracy of prognosisassessment was 85.3%. In the control group, there were 8 cases of ISSstage I, 13 cases of ISS stage II, 13 cases of ISS stage III and 8 casesof high-risk mutation detection, respectively. The accuracy of prognosisassessment was ${67.6}\%$ , and theaccuracy of prognosis assessment in the observation group wassignificantly higher than that in the control group. The overallsurvival rate and progression-free survival rate were 94.1% and 70.6% inthe observation group, and 82.4% and 52.9% in the control group,respectively, which were higher in the observation group $\left({P <{0.05}}\right)$ . Conclusion Gene sequencing technology is helpful to the early detection of MM andthe formulation of personalized treatment plan, improve the survivalrate and quality of life of patients, and has the value of applicationand promotion in clinical practice.

Objective To analyze the effectiveness of enzyme-linkedimmunosorbent assay (ELISA) and colloidal gold test in the detection ofhuman immunodeficiency virus (HIV) antibodies. Methods From January 2022to January 2024,50 cases of sentinel surveillance and contact populationof confirmed AIDS patients in our unit were selected as the observationtarget, and they were detected by ELISA and colloidal gold testrespectively, and the difference of patients’ detection results wasanalyzed. Results Among the 50 key populations, 36 were ultimatelydiagnosed and 14 were negative, which is the gold standard for thisstudy. The diagnostic effect of enzyme-linked immunosorbent assay issignificantly better than that of colloidal gold assay, and thedifference is statistically significant $\left({P <{0.05}}\right)$ . Conclusion The enzyme-linked immunosorbent assay (ELISA) is significantly moreeffective in HIV antibody detection than colloidal gold assay, and isworthy of being the preferred detection method.

Objective To systematically evaluate the applicationpotential of ${35}\mathrm{{kV}}$ modified polypropylene in the field of wire and cable. Methods Themechanical properties, thermal properties and electrical insulationproperties of the material were investigated by differential scanningcalorimetry (DSC), tensile test and electrical property evaluation.Results The modified polypropylene showed excellent mechanical strengthand thermal stability, and the performance of electrical insulation alsomet the high standards of industrial applications. Conclusion Thesystematic test of this study not only provides a scientific basis forfurther modification and optimization of polypropylene materials, butalso lays a solid foundation for its future market promotion, andprovides important theoretical and practical value for promoting thetechnological progress of wire and cable materials and realizing thedevelopment of environmentally friendly materials.

The article delves into real-time data processing methods for monitoring tool wear in computer numerical control (CNC) machine tools, with the aim of improving the overall accuracy of the tool monitoring system. The article also systematically reviews several mainstream data processing methods, including power spectrum analysis, wavelet transform, artificial neural network technology, and multi-sensor information fusion technology. Although these methods have their own advantages and disadvantages, a single method often fails to achieve ideal results when dealing with data in complex and changing processing environments. To overcome this challenge, this paper proposes a multi-sensor information fusion data processing method based on hybrid intelligent algorithms