In view of the problems of laborious personnel management, difficult object control and inadequate infrastructure conditions in the safety work of university laboratories, and based on the construction concept of "harmonious and safe campus", and combined with the current situation of safety management in the material laboratories of our college, we propose to comprehensively promote the informatization of laboratory safety management in four aspects: laboratory safety education, open booking of laboratories and equipment, purchase and supervision of hazardous chemicals, and laboratory safety risk assessment. By using information technology to reduce unsafe human behaviour, eliminate unstable physical conditions and make up for shortcomings in infrastructure construction, we provide new solutions to the difficulties of laboratory safety management.

The types and characteristics of hazards in university environmental laboratories are diverse, and the risk classification and prevention network barrier construction of hazards have a significant promoting effect on the management of hazards in university laboratories. The article adopts the method of system engineering to classify and statistically analyze the hazards in environmental laboratories; Based on the theory of accident risk chain, multi-level comprehensive evaluation method, and Murphy's law, a risk classification index system and prevention network barrier for environmental laboratory hazards have been constructed. The results indicate that: (1) The hazards in the laboratory are divided into two levels: risk factors and risk units. The risks of risk factors and risk units are divided into five levels: extreme danger, severe danger, significant danger, potential danger, and slightly dangerous. (2) Experimental materials, process equipment, environment, personnel, and safety management constitute the risk chain of experimental accidents. The occurrence of accidents is a chain event, and is greatly reduced by building layers of defense barriers. Building a prevention network barrier based on experimental projects, with division of labor and responsibility among all experimental personnel, interlocking of material, environmental, human and management, grading and precise supervision of hazardous units throughout the entire cycle, in all aspects, is a strong guarantee for laboratory safety.

Objective To analyze the impact of microbial detection technology on food inspection results. Method 100 samples of food to be tested from a testing institution between January 2023 and December 2023 were selected as the research subjects, all of which underwent fluorescence PCR and traditional national standard methods. The microbiological testing techniques were observed and recorded in the food inspection results. Result Among the 100 food samples to be tested, 52 were fruits, 34 were vegetables, and 14 were meat. Among the 10 food samples sampled, 4 were Escherichia coli, followed by 3 Staphylococcus aureus and 2 were Salmonella. According to the traditional national standard method, 4 were Escherichia coli, and 3 were Salmonella and Staphylococcus aureus; Among the 100 food samples from 3 categories, the highest contamination rates were found in raw animal meat, raw poultry meat, and aquatic products. A total of 17 samples were contaminated, and the most pathogenic bacteria detected were Escherichia coli, Staphylococcus aureus, and Salmonella. Conclusion Microbial detection technology can detect pathogenic microorganisms in food, distinguish specific types, and has good application value.

In order to better achieve the population health goals in the 14th Five-Year Plan, the information system of the centers for Disease Control and prevention at all levels from the national to the local level is constantly upgraded and improved, and the continuous improvement of information technology and the sharing of various types of data will promote the integration and application of emerging technologies, thus accelerating the development of information technology in the centers for disease control and prevention to intelligence. This paper explored the development path from digitization to intelligence in the information construction of disease prevention and control institutions (abbreviated as a disease control institution), analyzed the existing digitization and intelligent application of disease control institution, and provided solutions for the high-quality intelligent transformation of disease control institution; put forward that the information construction and development of disease control institution should be guided by the combination of digital innovation technology and expert experience, seized the current technological development opportunities, gave full play to their own professional and technical advantages, focused on improving their own technological transformation strength, uphold the characteristics of disease control, made up for functional defects, and achieve high-quality development of public health.

In the context of increasingly serious global diseases and health problems, the importance of biosafety concept has become increasingly prominent. As a country with biological diversity, China faces more serious public health risks. Laboratory safety, as an important link to strengthen biosafety protection, especially for the safety of pathogenic microorganism laboratories, is an important link to reduce the exposure and spread of dangerous goods, and ensure public health and life safety. Scientific laboratory safety management is of great importance. In order to improve the management level of pathogenic microbiology laboratory, the application of digital technology and the construction of information laboratory record management platform are of great application significance, which can effectively realize an efficient, integrated and standardized laboratory management mechanism, and provide support for the optimization and construction of public facilities such as pathogenic microbiology laboratory. This study will mainly explore the optimization path of the construction of the pathogenic microbiology laboratory record management platform, combined with the development requirements of the industry, social needs, etc., to build an efficient management system and improve the quality of laboratory safety management.

Objective To observe and analyze the clinical effect of drychemistry and urine sediment. Methods This study selected 150 patientsin our hospital from January 2022 to June 2022, divided into threegroups, experimental group of 50 patients with routine urine test usingdry chemical method, observation group of 50 patients with urine routinetest, the control group of dry chemistry method and urine sediment, andthe detection of the index of patients in urine routine test. Results The comparison of each index in the experimental group and theobservation group with routine urine test was less than that of urineroutine test in the control group using the combined method of drychemistry and urine sediment; the misdiagnosis rate in the experimentalgroup with a routine urine test using dry chemistry was $8\%$ , the missed diagnosis rate was 14%,the total error rate was 22%; the misdiagnosis rate in the observationgroup using the routine urine test was 10%, the missed diagnosis ratewas ${18}\%$ , the total error ratewas ${28}\%$ ; the misdiagnosis rateof the control group with routine urine test using combined drychemistry and urine sediment was 2%, the missed diagnosis rate was 2%,the total error rate was 4%, the total error rate of the experimentalgroups with routine dry chemistry urine testing and the observationgroups with routine urine sediment testing was greater than that of thecontrol group with routine urine testing using combined dry chemistryand urine sediment, the statistical significant difference wassignificant $\left({P<{0.05}}\right)$ . Conclusion After the active cooperation ofrelevant researchers and patients, the clinical effect observation ofurine routine test shows that the combination of dry chemistry and urinesediment is the best clinical effect.

Objective To investigate the effects of enrofloxacin andciprofloxacin residues in hot processed shrimp and to provide referencefor dietary risk assessment. Methods The shrimp (Penaeus indicus) afterdrug administration was selected as raw material, and a detection methodbased on RP-HPLC-FLD was established. The shrimp was processed by twohot processing methods: boiling and drying. The effects of water-shrimpratio (proportion of water to shrimp), boil holding time, dryingtemperature and drying time on residual concentrations of enrofloxacinand ciprofloxacin in shrimp were evaluated. Results During the boilingprocess, the residual concentrations of enrofloxacin and ciprofloxacinin shrimp decreased with the increase of water-to-shrimp ratio andboiling retention time, and the residual concentrations reached theminimum when the water-to-shrimp ratio was 5 . Under this condition, theeffect on the residual concentrations was significantly reduced afterthe boiling retention time reached ${20}\mathrm{\;{min}}$ . During the dryingprocess, the residual concentrations of enrofloxacin and ciprofloxacinincreased with increasing drying temperature and remained basicallyunchanged between 150 and ${180}^{\circ }\mathrm{C}$ . When thedrying temperature was set at ${150}^{\circ }\mathrm{C}$ , the residualconcentration increased with the increase of drying time and remainedbasically unchanged between 5 and 8 min. Studies have shown that boilingcan significantly reduce the residual concentrations of enrofloxacin andciprofloxacin in shrimp, while drying can cause the residualconcentrations to increase on the basis of boiling. The overallprocessing factor of enrofloxacin and ciprofloxacin was less than 1 ,indicating that the residual concentrations of enrofloxacin andciprofloxacin in dried shrimp were lower than those in raw shrimp. Conclusion The study in this paper can help processing enterprises orquality supervision departments to effectively evaluate the impact ofantibiotic residues in hot processing shrimp, and put forward relevantsuggestions on food safety.

Objective To understand the pathogenic spectrum compositionof bacterial diarrhea in Jiangxia District of Wuhan, to explore thevariation and epidemic changes of the main pathogenic bacteria inJiangxia District of Wuhan in recent years, and to provide scientificbasis for the diagnosis and prevention and control of bacterialdiarrhea. Methods 341 specimens of patients with bacterial diarrheasyndrome in Jiangxia District of Wuhan from 2021 to 2023 were collected,and a variety of intestinal pathogenic bacteria were detected, and thedrug resistance of the detected pathogenic bacteria was analyzed. Results The highest detection rate in 2021-2023 was Salmonella,accounting for 42.82%(146/341) of cases detected; next is Vibrio, with adetection rate of ${16.42}\%\left({{56}/{341}}\right)$ ; thethird place is Escherichia coli, with a detection rate of 6.74%(23/341).In the typing results, the most commonly detected strains of Salmonella,Vibrio, and Escherichia coli were Salmonella enterica, Vibrioparahaemolyticus, and pathogenic Escherichia coli, with detection ratesof 14.37%, 13.20%, and 3.52%, respectively. Among the 341 detectedbacteria, the age group of 20~40 had the highest number of detectedbacteria, with 223, accounting for 65.40% of the total; 118 strains weredetected in the age group of 40~60, accounting for 34.60% of the total.There is a statistically significant difference between the two agegroups $\left({{\chi }^{2}= {57.484}, P<{0.001}}\right)$ . Conclusion Salmonella is the main pathogenic bacteria of bacterial diarrhea in Jiangxia District of Wuhan from 2021 to2023.

In order to improve the comprehensive service capabilities of medical device inspection and testing laboratories, the inspection and testing business activities are empowered by digital means, and complete the digitization of the entire lifecycle of laboratory business. This article proposed a construction idea and design plan for the digitization of provincial medical device inspection institutions laboratories, designed the design principles, technical routes, and architecture of digital laboratories, constructed application scenarios for business and digital capabilities, strengthened the quality system of inspection and testing business, and utilized risk monitoring analysis and application of daily commissioning, supervision sampling, registration inspection, rapid evaluation, and defect/warning/recall to better serve supervision and enterprises.

Objective To study and improve medical equipment fault diagnosis techniques by utilizing system state detection methods to quickly and accurately diagnose faults in medical equipment without schematics, thereby enhancing the efficiency and accuracy of equipment maintenance. Methods This study employed the system state detection method, using online testers and digital oscilloscopes to establish a system state database for the equipment. The study involved 20 common medical devices from a hospital, including blood oxygen monitors and laminar flow fan frequency converters. When equipment failures occurred, traditional fault localization methods were first used to narrow the fault range to the board level. Subsequently, online testers and digital oscilloscopes were used for component comparison testing, combined with previous successful cases for fault diagnosis. Results Among the 20 medical devices, 18 were successfully diagnosed and repaired, achieving a fault diagnosis accuracy rate of 90%. Specific cases included successfully eliminating ADC chip faults in the PM9000 monitor's blood oxygen board and E2PROM faults in the laminar flow fan frequency converter. By establishing a system state database and case database, the efficiency of equipment fault diagnosis was significantly improved, with the average diagnosis time reduced by 30%. Conclusion System state detection can effectively enhance the accuracy of medical equipment fault diagnosis and should be further promoted to optimize maintenance management.