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Structural Elucidation and Anti-inflammatory Activity of Neutral Polysaccharide from Orchis chusua D. Don
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Zhiyan YANG1, Yufan WANG1, Yasen AYZUKRAM1, 2, Yanli WANG1, Ruijie WEI1, Yulu GU1, Nuerxiati REHEBATI1, 2, *, Inumu HULSIDAN3, *
Science and Technology of Food Industry | 2026, 47(8) : 100 - 108
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Science and Technology of Food Industry | 2026, 47(8): 100-108
• Research and Investigation •
Structural Elucidation and Anti-inflammatory Activity of Neutral Polysaccharide from Orchis chusua D. Don
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Zhiyan YANG1, Yufan WANG1, Yasen AYZUKRAM1, 2, Yanli WANG1, Ruijie WEI1, Yulu GU1, Nuerxiati REHEBATI1, 2, *, Inumu HULSIDAN3, *
Affiliations
  • 1Xinjiang Key Laboratory of Clean Conversion and High Value Utilization of Biomass Resources, School of Chemistry and Chemical Engineering, Yili Normal University, Yining 835000, China
  • 2Key Laboratory of Natural Product Chemistry and Application, Department of Education, Xinjiang Uygur Autonomous Region, School of Chemistry and Chemical Engineering, Yili Normal University, Yining 835000, China
  • 3Xinjiang Uygur Autonomous Region, Xinjiang Medical University, Urumqi 830017, China
Published: 2026-04-15 doi: 10.13386/j.issn1002-0306.2025040212
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To systematically investigate the structural features and anti-inflammatory activity of neutral polysaccharide (USP-N) from Orchis chusua D. Don, a medicinal and edible plant was selected. The structure of USP-N was comprehensively elucidated through partial acid hydrolysis, Smith degradation, methylation analysis, and 2D-NMR spectroscopy. Its anti-inflammatory effects were evaluated using a zebrafish inflammation model. Structural analysis revealed that the main chain of USP-N was composed of alternating β-1,4-linked glucose (38.5%) and mannose (33.8%), forming a glucomannan backbone. The side chains contained small amounts of rhamnose, arabinose, and galactose, with some mannose residues featuring 2-O-acetyl groups. Bioactivity assays demonstrated that USP-N treatment significantly suppressed LPS-induced nitric oxide (NO) release (P<0.0001) and inhibited neutrophil migration to the tail injury site in zebrafish (P<0.0001). Furthermore, dose-dependent reductions in neutrophil and macrophage recruitment to the caudal region following mechanical injury were observed. This study provides a theoretical foundation for applying Orchis chusua D. Don polysaccharides in functional foods and pharmaceutical development.

Orchis chusua D. Don  /  polysaccharide  /  methylation  /  2D NMR  /  anti-inflammatory activity
杨智艳, 王宇帆, 阿依左克拉木·牙森, 王艳丽, 魏瑞杰, 顾雨露, 热合巴提·努尔夏提, 胡尔西丹·伊麻木. 中亚白及中性多糖的结构解析及抗炎活性研究. 食品工业科技, 2026 , 47 (8) : 100 -108 . DOI: 10.13386/j.issn1002-0306.2025040212
Zhiyan YANG, Yufan WANG, Yasen AYZUKRAM, Yanli WANG, Ruijie WEI, Yulu GU, Nuerxiati REHEBATI, Inumu HULSIDAN. Structural Elucidation and Anti-inflammatory Activity of Neutral Polysaccharide from Orchis chusua D. Don[J]. Science and Technology of Food Industry, 2026 , 47 (8) : 100 -108 . DOI: 10.13386/j.issn1002-0306.2025040212
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Year 2026 volume 47 Issue 8
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Article Info
doi: 10.13386/j.issn1002-0306.2025040212
  • Receive Date：2025-04-17
  • Online Date：2026-10-24
  • Published：2026-04-15
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  • Received：2025-04-17
Affiliations
    1Xinjiang Key Laboratory of Clean Conversion and High Value Utilization of Biomass Resources, School of Chemistry and Chemical Engineering, Yili Normal University, Yining 835000, China
    2Key Laboratory of Natural Product Chemistry and Application, Department of Education, Xinjiang Uygur Autonomous Region, School of Chemistry and Chemical Engineering, Yili Normal University, Yining 835000, China
    3Xinjiang Uygur Autonomous Region, Xinjiang Medical University, Urumqi 830017, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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