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Unveiling the Antioxidant Mechanism of Flavonoids in Different Varieties of Daylily via Integrating Widely Targeted Metabolomics, Network Pharmacology and Molecular Docking
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Zhihao LI1, 2, 3, Haizhen WANG1, 2, 3, Zhenyu LIU4, Han WANG5, Shang GUO1, 2, 3, 6, *, Yongxia FU1, 3, *
Science and Technology of Food Industry | 2026, 47(13) : 334 - 346
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Science and Technology of Food Industry | 2026, 47(13): 334-346
• Analysis and Determination •
Unveiling the Antioxidant Mechanism of Flavonoids in Different Varieties of Daylily via Integrating Widely Targeted Metabolomics, Network Pharmacology and Molecular Docking
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Zhihao LI1, 2, 3, Haizhen WANG1, 2, 3, Zhenyu LIU4, Han WANG5, Shang GUO1, 2, 3, 6, *, Yongxia FU1, 3, *
Affiliations
  • 1Shanxi Institute for Functional Food, Shanxi Agricultural University, Taiyuan 030031, China
  • 2College of Horticulture, Shanxi Agricultural University, Taigu 030801, China
  • 3Shanxi Provincial Key Laboratory of Agricultural Product Nutrition, Health Research and Processing Technology, Taiyuan 030031, China
  • 4College of Biomass Science & Engineering, Sichuan University, Chengdu 610065, China
  • 5College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
  • 6College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China
Published: 2026-07-01 doi: 10.13386/j.issn1002-0306.2025070338
Outline
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Hemerocallis citrina Baroni (daylily) is a medicinal and edible food with flavonoids as its core active ingredient. Daylily showed significant differences in flavonoids across varieties, thereby impacting their health benefits. This study selected four daylily varieties in the Datong, namely Datong (DT), Mallian (ML), Mengzi (MZ), and Huaiyang (HY), for metabolomics to unravel their flavonoid composition. DT exhibited the highest total flavonoid content (TFC), while MZ demonstrated the strongest antioxidant potential. There were ten highly differential flavonoid metabolites in four daylily varieties that had a significant positive correlation with their antioxidant activity. Notably, the levels of these metabolites in MZ were the highest, corresponding to its strongest antioxidant activity. Network pharmacology analysis revealed that antioxidant targets associated with key flavonoids in daylily were primarily focused on PI3K-AKT signaling pathway, identifying AKT1 and EGFR as the core antioxidant targets. Molecular docking results demonstrated their interaction mechanisms, suggesting that daylily flavonoids might attenuate the oxidative stress. This research provides critical insights for selecting and cultivating daylilies with enhanced health benefits.

daylily  /  flavonoids  /  metabolomics  /  network pharmacology  /  molecular docking
李志豪, 王海珍, 刘振宇, 王晗, 郭尚, 付永霞. 基于广泛靶向代谢组学、网络药理学和分子对接揭示不同品种黄花菜黄酮的抗氧化机制. 食品工业科技, 2026 , 47 (13) : 334 -346 . DOI: 10.13386/j.issn1002-0306.2025070338
Zhihao LI, Haizhen WANG, Zhenyu LIU, Han WANG, Shang GUO, Yongxia FU. Unveiling the Antioxidant Mechanism of Flavonoids in Different Varieties of Daylily via Integrating Widely Targeted Metabolomics, Network Pharmacology and Molecular Docking[J]. Science and Technology of Food Industry, 2026 , 47 (13) : 334 -346 . DOI: 10.13386/j.issn1002-0306.2025070338
Appendix
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Year 2026 volume 47 Issue 13
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Article Info
doi: 10.13386/j.issn1002-0306.2025070338
  • Receive Date：2025-07-28
  • Online Date：2026-10-24
  • Published：2026-07-01
Article Data
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History
  • Received：2025-07-28
Affiliations
    1Shanxi Institute for Functional Food, Shanxi Agricultural University, Taiyuan 030031, China
    2College of Horticulture, Shanxi Agricultural University, Taigu 030801, China
    3Shanxi Provincial Key Laboratory of Agricultural Product Nutrition, Health Research and Processing Technology, Taiyuan 030031, China
    4College of Biomass Science & Engineering, Sichuan University, Chengdu 610065, China
    5College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
    6College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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