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Improvement Mechanism of Raw Foxtail Millet Prolamin on High-Fat Diet Combined with STZ Induced Diabetic Mice Based on Gut Microbiota and Hepatic Transcriptomics
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Yongxia FU1, 2, Han WANG2, Zhenyu LIU3, Haizhen WANG1, Shang GUO1, Qun SHEN2, *
Science and Technology of Food Industry | 2026, 47(8) : 407 - 416
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Science and Technology of Food Industry | 2026, 47(8): 407-416
• Nutrition and Healthcare •
Improvement Mechanism of Raw Foxtail Millet Prolamin on High-Fat Diet Combined with STZ Induced Diabetic Mice Based on Gut Microbiota and Hepatic Transcriptomics
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Yongxia FU1, 2, Han WANG2, Zhenyu LIU3, Haizhen WANG1, Shang GUO1, Qun SHEN2, *
Affiliations
  • 1Shanxi Institute for Functional Food, Shanxi Agricultural University, Taiyuan 030031, China
  • 2College of Food Science and Nutritional Engineering, China Agricultural University/National Center of Technology Innovation (Deep Processing of Highland Barley) in Food Industry/Beijing Key Laboratory of Plant Protein and Grain Processing/National Engineering Research Center for Fruit and Vegetable Processing, Beijing 100083, China
  • 3College of Biomass Science & Engineering, Sichuan University, Chengdu 610065, China
Published: 2026-04-15 doi: 10.13386/j.issn1002-0306.2025030396
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Both raw and cooked millet prolamin (RFMP and CFMP) exhibited significant functions in improving glucose metabolism. Compared to RFMP, the protein quality of CFMP significantly decreased. Therefore, RFMP was more valuable as a potential food-derived hypoglycemic functional substance. In order to study the effects of RFMP on the intestinal flora and liver of type 2 diabetes (T2D) mice, C57BL/6J mice were used as the objects, and T2D models were established by high-fat diet combined with streptozotocin. The T2D mice were continuously intervened with RFMP for five weeks. Subsequently, 16S rRNA sequencing and transcriptomics technology were employed to analyze the composition of the gut microbiota and liver gene expression, respectively. The results showed that RFMP could improve glucose metabolism by alleviating the intestinal flora disorder induced by diabetes. At the genus level, RFMP intervention significantly increased the abundance of Lactobacillus, norank_f_Muribaculaceae, and Lachnospiraceae_NK4A136_group in T2D mice. Liver transcriptome results showed that the intervention of RFMP upregulated the expression levels of Fgf21, Dusp1, Rasgrp1, and Hk3, while downregulated the expression level of Pck1, which were the key genes for regulating glucose metabolism. This study elucidated the mechanism of improving glucose metabolism with RFMP, providing a theoretical basis for the development of functional FMP product.

diabetes  /  raw foxtail millet prolamin  /  gut microbiota  /  transcriptome  /  mechanism
付永霞, 王晗, 刘振宇, 王海珍, 郭尚, 沈群. 基于肠道菌群和转录组学分析生小米醇溶蛋白对高脂膳食联合STZ诱导的糖尿病小鼠的改善机制. 食品工业科技, 2026 , 47 (8) : 407 -416 . DOI: 10.13386/j.issn1002-0306.2025030396
Yongxia FU, Han WANG, Zhenyu LIU, Haizhen WANG, Shang GUO, Qun SHEN. Improvement Mechanism of Raw Foxtail Millet Prolamin on High-Fat Diet Combined with STZ Induced Diabetic Mice Based on Gut Microbiota and Hepatic Transcriptomics[J]. Science and Technology of Food Industry, 2026 , 47 (8) : 407 -416 . DOI: 10.13386/j.issn1002-0306.2025030396
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Year 2026 volume 47 Issue 8
108
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Article Info
doi: 10.13386/j.issn1002-0306.2025030396
  • Receive Date：2025-04-01
  • Online Date：2026-10-24
  • Published：2026-04-15
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History
  • Received：2025-04-01
Affiliations
    1Shanxi Institute for Functional Food, Shanxi Agricultural University, Taiyuan 030031, China
    2College of Food Science and Nutritional Engineering, China Agricultural University/National Center of Technology Innovation (Deep Processing of Highland Barley) in Food Industry/Beijing Key Laboratory of Plant Protein and Grain Processing/National Engineering Research Center for Fruit and Vegetable Processing, Beijing 100083, China
    3College of Biomass Science & Engineering, Sichuan University, Chengdu 610065, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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