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Objective To explore the protective effects of Panax notoginseng fibrous root extract on alcoholic liver disease in mice. Methods A total of 50 male C57BL/6J mice were randomly divided into 5 groups of 10 mice each: The control group, the model group, the low dose group (67.5 mg/kg), the medium dose group (135.0 mg/kg) and the high dose group (270.0 mg/kg). The control group and the model group were gavaged with pure water, while the Panax notoginseng fibrous root extract groups were given with the corresponding concentrations of the test substance at 20 mL/kg. The Panax notoginseng fibrous root extract groups and model group were gavaged with 40% ethanol (10 mL/kg) 5 hours late for 14 days. The Panax notoginseng fibrous root extract groups and model group were fasted for 16 hours after the last gavage, then each was given 40% ethanol at 20 mL/kg. After weighing the fasting body weight of each group of mice, blood was collected from the abdominal aorta and the liver was removed and weighed. Finally, determined the biochemical indices of serum and liver, and the levels of interleukin-1β (IL-1β) and interleukin-6 (IL-6) in liver. Results Compared with the model group, the medium and high dose groups of the serum triglyceride (TG), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were significantly decreased (P<0.05 or P<0.01). But the superoxide dismutase (SOD), glutathione (GSH) and glutathione peroxidase (GSH-Px) in liver was significantly increased (P<0.05 or P<0.01), while the content of malondialdehyde (MDA) was extremely significantly decreased (P<0.01). The content of TG in liver of high dose group was lower than the model group (P<0.01), the difference was statistical significance. Besides, the levels of IL-1β of the low and high dose groups were significantly decreased compared with the model group (P<0.05 or P<0.01). Conclusion The Panax notoginseng fibrous root extract has a good protective effect on hepatic injury induced by alcohol in mice.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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