Effective monitoring of chloride ion indicators in precision treated effluent plays a crucial role in ensuring the quality of the effluent, adjusting operational processes, and extending operating cycles. According to the theory of ion exchange equilibrium, the operating characteristics, effluent quality, and resin regeneration requirements of hydrogen type and ammonium type operation modes for precision treatment were analyzed and compared. Through laboratory simulation experiments and tracking experiments of the operating cycle of a precision treated mixed bed in a certain power plant, the migration characteristics of chloride ions in the effluent of precision treatment were mainly studied. The results show that, the requirement for regeneration degree of resin in the hydrogen stage is low, and the main focus of this stage is desalination, which is not prone to chlorine leakage. As the pH value of the effluent increases during the conversion stage, the requirement for resin regeneration also increases. When the condensate contains chloride ions, chloride ion displacement is prone to occur. During ammonium type operation, the mixed bed no longer focuses on desalination, and the mass concentration of chloride ions in the effluent is equivalent to that in the condensate. Therefore, effective monitoring of chloride ions is necessary for ensuring the quality of effluent water, especially during ammonium type operation. At the same time, using chloride ions as one of the monitoring indicators can not only ensure the quality of effluent water effectively, but also guide the adjustment of precision treatment operation process, and significantly extend the precision treatment operation cycle while ensuring the safe operation of the unit.