High-temperature environments can lead to the deterioration of the heat dissipation performance of indirect air cooling towers. Air inflow spray pre-cooling is an effective method to enhance the heat dissipation performance of indirect air cooling towers. Taking a 2×350 MW indirect air cooling unit in northwest China as the research object, a numerical model coupling the spray evaporation with the ventilation and heat dissipation of the indirect air cooling tower is established to study the effect of air inflow spray pre-cooling on the performance of the indirect air cooling tower with different environmental factors. The results show that crosswind can carry the spray downstream, causing the spray to accumulate and benefiting the radiators in the leeward area the most. The performance improvement of the radiators in the windward area decreases with the increasing wind speed, while the radiators in the side area even experience performance degradation at medium to high wind speeds. Additionally, as the wind speed increases, the spray flows out of the annular evaporation zone, resulting in some pre-cooled ambient air failing to enter the radiators and leading to spray waste and reduced effectiveness. The improvement rate of heat dissipation in the indirect air cooling tower after air inflow spray pre-cooling decreases at first and then increases with the increasing wind speed. At an ambient humidity of 40%, the heat dissipation improvement rate decreases from 5.65% at 0 m/s to a minimum of 2.03% at 8 m/s, and then rises to 3.98% at 12 m/s. The effectiveness of air inflow spray pre-cooling weakens with the increasing ambient humidity. Under windless conditions, as the humidity increases from 20% to 80%, the heat dissipation improvement rate of the indirect air cooling tower decreases from 6.4% to 2.4%.