As an important part of postmodern literature, American postmodern science fiction implicates the unique aesthetic thought of Zen, which is significant for the interdisciplinary postmodern comparative study in China and the West. Starting from the relation between American postmodern science fiction and Zen, this article mainly analyzes the classic works, the Dune Chronicles and the Hyperion Cantos. Based on "the method of no differentiation" that belongs to the vital thinking mode of Chinese Zen aesthetic thought, it discusses the connections and distinctions between the artificial intelligence and all living things in the fiction, and then shows the dilemma of language in the light of Zen aesthetics. Meanwhile, the analyzing focus is on the path to enlightenment for all beings, revealing the true direction of the future human race, and further suggesting that the Zen aesthetics offer useful lessons for understanding the self and the other in the context of the rise of artificial intelligence. Moreover, in the post-theoretical era, the aesthetic thought of Zen, including "the method of no differentiation", as the idea that originates from China, is another example for the construction of Chinese discourse in the field of foreign literary studies.