Closely following the Guidelines on Popular Science Creation for Scientific and Technical Professionals issued by the General Office of the China Association for Science and Technology, and drawing on the science popularization work carried out by the China Anti-Cancer Association in recent years, this paper focuses on the book Hello, Stomach! as a case study from the Exemplary Works on Popular Science Creation for Scientific and Technical Professionals, with an emphasis on reviewing and elaborating the book's creative process. The production process of this best-selling popular science book is highly consistent with the audience-targeting strategies, the basic principles of "scientificity and authenticity, readability and accessibility, and insightfulness and significance, "as well as the systematic creation concept for popular science books proposed by the Guidelines. The Guidelines also provide a powerful lever for the China Anti-Cancer Association to carry out its future science popularization work.