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Current status and perspectives of patient-derived xenograft models in liver cancer research
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Lin-Han Jiang1, 2, Xiao-Xia Tan1, 2, Jun Li3, Song Su4, Ya-Ling Li1, *
Medical Journal of Chinese People’s Liberation Army | 2021, 46(10) : 1029 - 1033
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Medical Journal of Chinese People’s Liberation Army | 2021, 46(10): 1029-1033
• Review •
Current status and perspectives of patient-derived xenograft models in liver cancer research
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Lin-Han Jiang1, 2, Xiao-Xia Tan1, 2, Jun Li3, Song Su4, Ya-Ling Li1, *
Affiliations
  • 1Department of Pharmacy, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China
  • 3Department of Chinese Traditional Medicine, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China
  • 4Department of Hepatobiliary Surgery, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China
  • 2School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, China
Published: 2021-10-28 doi: 10.11855/j.issn.0577-7402.2021.10.12
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Patient-derived xenograft (PDX) model of liver cancer is created by transplanting the primary tumor tissue of patients with liver cancer into immunodeficient mice to simulate the biological characteristics of primary tumors, similar genetic characteristics and tumor heterogeneity with patients, which has been widely used in liver cancer research and plays an important role in drug research and clinical tumor treatment. This review firstly summarize the methodology to establish PDX models of liver cancer, four new PDX models of live cancer, and then go over recent application and function of liver cancer PDX models in basic cancer research and in preclinical explorations and finally give our perspectives on the future prospects of liver cancer PDX models.

liver cancer  /  patient-derived xenograft model  /  basic research  /  preclinical research  /  drug assessment
Lin-Han Jiang, Xiao-Xia Tan, Jun Li, Song Su, Ya-Ling Li. Current status and perspectives of patient-derived xenograft models in liver cancer research[J]. Medical Journal of Chinese People’s Liberation Army, 2021 , 46 (10) : 1029 -1033 . DOI: 10.11855/j.issn.0577-7402.2021.10.12
Funding
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  • National Natural Science Foundation of China(81803019)
Appendix
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Year 2021 volume 46 Issue 10
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Article Info
doi: 10.11855/j.issn.0577-7402.2021.10.12
  • Receive Date：2021-01-13
  • Online Date：2025-12-19
  • Published：2021-10-28
Article Data
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History
  • Received：2021-01-13
  • Revised：2021-03-03
Funding
National Natural Science Foundation of China(81803019)
Affiliations
    1Department of Pharmacy, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China
    3Department of Chinese Traditional Medicine, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China
    4Department of Hepatobiliary Surgery, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China
    2School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, China

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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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