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Research progress on the role of neutrophil extracellular traps in tumor microenvironment
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Xue-Ni Ma, Hui-Mei Xu, De-Kui Zhang*
Medical Journal of Chinese People’s Liberation Army | 2022, 47(4) : 407 - 411
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Medical Journal of Chinese People’s Liberation Army | 2022, 47(4): 407-411
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Research progress on the role of neutrophil extracellular traps in tumor microenvironment
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Xue-Ni Ma, Hui-Mei Xu, De-Kui Zhang*
Affiliations
  • Department of Gastroenterology, the Second Hospital of Lanzhou University, Lanzhou 730030, China
Published: 2022-04-28 doi: 10.11855/j.issn.0577-7402.2022.04.0407
Outline
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Neutrophil extracellular trap (NETs) is a kind of DNA-based skeleton released by neutrophils to the outside of the cell, in which a variety of granular proteins, proteolytic enzymes, antibacterial peptides, and other network structures are embedded.In recent years, studies have confirmed that NETs are highly expressed in a variety of tumors, and tumor microenvironment (TME)is a special environment for tumor cell survival and development, including cellular and non-cellular components. This article mainly explains that TME can stimulate the formation of NETs, and NETs can also promote tumor proliferation, invasion and metastasis by affecting tumor cells, immune cells, endothelial cells, epithelial cells, fibroblasts and extracellular matrix in TME. Finally, the clinical application prospects of NETs as tumor markers and potential therapeutic targets are discussed.

neutrophil extracellular trap  /  tumor microenvironment  /  research progress
Xue-Ni Ma, Hui-Mei Xu, De-Kui Zhang. Research progress on the role of neutrophil extracellular traps in tumor microenvironment[J]. Medical Journal of Chinese People’s Liberation Army, 2022 , 47 (4) : 407 -411 . DOI: 10.11855/j.issn.0577-7402.2022.04.0407
Funding
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  • National Natural Science Foundation of China(81770525)
Appendix
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Year 2022 volume 47 Issue 4
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253
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Article Info
doi: 10.11855/j.issn.0577-7402.2022.04.0407
  • Receive Date：2021-03-31
  • Online Date：2025-12-17
  • Published：2022-04-28
Article Data
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History
  • Received：2021-03-31
  • Accepted：2021-06-15
Funding
National Natural Science Foundation of China(81770525)
Affiliations
    Department of Gastroenterology, the Second Hospital of Lanzhou University, Lanzhou 730030, China

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Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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