Obstructive sleep apnea hypopnea syndrome (OSAHS) is a common sleep disorder, which is caused by collapse and obstruction of upper airway during sleep, accompanied by snoring, daytime drowsiness and sleep structure disorder. OSAHS is closely related to cardiovascular disease, metabolic disorder, diabetes, cognitive impairment and tumors. The prevalence rate of OSAHS is relatively high, which significantly increases the social and economic burden. Therefore, early diagnosis and treatment of OSAHS is necessary. miRNA is a non-coding small RNA molecule, which can play important role in a variety of important biological functions by regulating the expression of target genes. In recent years, some studies indicated that miRNA could be used as a biomarker for early diagnosis of hypertension, coronary heart disease, diabetes and tumors. Recently, a large number of studies showed that miRNA can be used in diagnosis, assessment, and therapeutic target of OSAHS with its complications. This review summarizes the research progress on the role of miRNA in OSAHS with its complications.
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |