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Progress in the mechanism of stem cell derived extracellular vesicles in treatment of early onset ovarian insufficiency
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Wen-Zhuo Zeng, Xin-Yi Huang, Shu-Li Xu, Xiao-Feng Sun*
Medical Journal of Chinese People’s Liberation Army | 2023, 48(12) : 1467 - 1472
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Medical Journal of Chinese People’s Liberation Army | 2023, 48(12): 1467-1472
• Review •
Progress in the mechanism of stem cell derived extracellular vesicles in treatment of early onset ovarian insufficiency
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Wen-Zhuo Zeng, Xin-Yi Huang, Shu-Li Xu, Xiao-Feng Sun*
Affiliations
  • Medical College, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China
Published: 2023-12-28 doi: 10.11855/j.issn.0577-7402.1106.2023.0227
Outline
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Premature ovarian insufficient (POI) is one of the important causes of infertility in woman of reproductive age. At present, the clinical treatment of POI is limited and the therapeutic effect is not ideal. Extracellular vesicles derived from stem cells have attracted the attention of many researchers at home and abroad as a new cell-free therapy. Many animal experiment study shows that a variety of extracellular vesicles from stem cells carry microRNAs, lncRNAs, lipids, proteins, and other bioactive substances, improve ovarian function, affect granulosa cell proliferation and apoptosis, promote ovarian angiogenesis, and reduce oxidative stress response, thus playing a therapeutic role on POI. This article will review the mechanisms of extracellular vesicles in treatment of POI, and provide evidence for the application of extracellular vesicles in clinical treatment of POI.

premature ovarian insufficient  /  extracellular vesicles  /  exosomes  /  stem cell-derived
Wen-Zhuo Zeng, Xin-Yi Huang, Shu-Li Xu, Xiao-Feng Sun. Progress in the mechanism of stem cell derived extracellular vesicles in treatment of early onset ovarian insufficiency[J]. Medical Journal of Chinese People’s Liberation Army, 2023 , 48 (12) : 1467 -1472 . DOI: 10.11855/j.issn.0577-7402.1106.2023.0227
Funding
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  • National Natural Science Foundation of China(81774362)
  • National Natural Science Foundation of China(81303004)
  • Natural Science Foundation of Hunan Province(2018JJ2290)
  • Natural Science Foundation of Changsha City(kq2208187)
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Year 2023 volume 48 Issue 12
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Article Info
doi: 10.11855/j.issn.0577-7402.1106.2023.0227
  • Receive Date：2022-05-17
  • Online Date：2025-11-24
  • Published：2023-12-28
Article Data
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History
  • Received：2022-05-17
  • Accepted：2022-07-09
Funding
National Natural Science Foundation of China(81774362)
National Natural Science Foundation of China(81303004)
Natural Science Foundation of Hunan Province(2018JJ2290)
Natural Science Foundation of Changsha City(kq2208187)
Affiliations
    Medical College, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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