Latest ArticlesHerein, we utilized nucleic acids induced peptide co-assembly strategy to develop novel nucleic acids induced peptide-based AIE (NIP-AIE) nanoparticles. Strong fluorescent of AIE could be observed when a little amount of nucleic acids was added into the peptide solution, and the intensity could be regulated by the concentration of nucleic acids. This AIE nanoparticle with good biocompatibility could achieve fast cell imaging. It is also proved that the fluorescence intensity of AIE decreased with time, which indicates that the reducible cross-linkers of Wpc peptide by GSH and nanoparticles gradually disintegrate in cell. Based on the different of AIE fluorescence signals which regulated by the formation and disintegration of nanoparticles, this AIE system is expected to be used for real-time monitoring of drug release from peptide-based nano carriers in vivo or in vitro, and may provide a new platform for the construction of other organic AIE nanoparticles.
Dinuclear ytterbium and erbium based bifunction complexes Ln2L2(depma2)Cl2 (1-Ln, Ln=Yb and Er, H2L=N1, N3-bis(salicylideneimino)diethylenetriamine, depma2 = dimerized 9-diethyl-phosphonomethylanthracene) are reported. They undergo thermo-induced consecutive phase transitions, first the dissociation of depma2 ligand forming LnL(depma)Cl (2-Ln) and then the release of chloroethane forming LnL(epma) (3-Ln, epma=9-ethylphosphonomethylanthrancene). The structural transformations are accompanied with synergetic switch of the luminescence in visible and NIR regions and also magnetic dynamics.
This device is aimed at ensuring that the sample is uniformly and equivalently reacted with the antibody on the NC membrane in each test when the microfluidic liquid system is introduced to the chip. In this study, the developed microfluidic chip can avoid the presence of the sample and conjugate pads in the chip, while the precision of the chromatography system can be greatly improved using the same particles, NC membrane and antibody alongside the traditional strip. The results, taking the detection of cTnI as an example, revealed that the coefficient of variation (CV) is controlled within 4%, while the maximum record of the contrast chromatographic reagent strip can reach 15%. Additionally, the detection sensitivity can maintain the same order of magnitudes with that of the traditional chromatographic strip. With the results, the determination correlation of the developed microfluidic chip has been greatly improved. In addition, the CV of the chip in this study is greatly improved in comparison with that of the traditional strip. The biggest improvement lies in the mixing between the sample and the microspheres, indicating that this is a new approach to improve the CV of the traditional strip.
Nanowires (NWs) and self-assemble nanostructures made of chalcogenide semiconductor nanocrystals (NCs) are of great interests to the fundamental studies and practical applications. In this study, we reported a seeded-mediated growth of AgInS2 NWs and their intriguing self-assembly nanostructures with fingerprint-like shape. The key to the formation and self-assembly of AgInS2 NWs was the presence of In-S species that was a type of molecular metal chalcogenide complexes, serving as specific inorganic ligands for the growth of NWs and cross-linker molecules for the self-assembly of fingerprint-like nanostructures. Systematic studies were carried out to investigate the reaction factors, including the thermodynamics, amount and type of In precursors, and 1-dodecanethiol usage, to the success of the desired products.
It is always highly pursued to develop efficient and durable catalysts for catalytic applications. Herein, intermetallic PdBi aerogels with tunable activity were prepared successfully via a surfactant-free spontaneous gelation process. The prepared PdBi aerogels have a three-dimensional high porous structure and plentiful active sites pervaded on the ultrathin interlinked nanowires network. These unique structures, as well as the synergistic effect between Pd and Bi, can accelerate mass and electron transfer, and improve the atom utilization ratio of Pd atoms to promote the catalytic efficiency. As a proof-of-concept application, the optimized Pd2Bi1 aerogels exhibit 4.2 and 6.2 times higher catalytic activity for the reduction of 4-nitrophenol (4-NP) and methylene blue (MB) than those of commercial Pd/C, respectively. With the introduction of non-noble metal of Bi, the cost of the resulted PdBi aerogels can be dropped significantly while the catalytic capability of PdBi aerogel will be improved sharply. This strategy will bring good hints to rationally design fine catalysts for various applications.
An efficient PET-based probe, in which the ferrocene quencher and the naphthalimide fluorophore are linked by a disulfide bond, has been developed. This probe can be activated by GSH with fluorescence a turn-on response for blocking the PET process. In addition, it was successfully applied for distinguishing cancer cells from normal cells
The power conversion efficiency (PCE) of OFQx-T: PC71BM blend films reaches 7.59%. On this basis, ternary organic solar cells (OSCs) were fabricated with ITIC or PTB7-Th as the third component. The ternary OSCs with 50 wt% ITIC in acceptors exhibits an enhanced efficiency, from 7.59% to 8.17%. Also, the PCE of ternary OSCs with 50 wt% PTB7-Th in donors achieves 8.72%, which is 13% higher than that of binary OSCs. The PCE improvement of two ternary OSCs is mainly due to the increase of short-circuit current density (Jsc), which can be attributed to the complementary absorption spectra and improved film morphology. This work suggests that the selection of an appropriate third component plays a critical role in improving the PCE of ternary OSCs.
Near-infrared (NIR) small molecular organic dyes as photothermal agents for cancer photothermal therapy (PTT) have attracted considerable research attention. Herein, two donor-acceptor-donor (D-A-D) structured NIR dyes, BBTT and SeBTT, are rationally designed, where the only difference is one heteroatom within the acceptor unit varying from sulfur to selenium (Se). More importantly, SeBTT NPs exhibit stronger NIR absorbance and higher photothermal conversion efficiency (PTCE ≈ 65.3%). In vivo experiments illustrate that SeBTT NPs can be utilized as a high contrast photoacoustic imaging (PAI) agent, and succeed in tumor suppression without noticeable damage to main organs under NIR photoirradiation. This study presents an effective molecular heteroatom surgery strategy to regulate the photothermal properties of NIR small molecules for enhanced PAI and PTT.
A series of triphenylamine (TPA) derivatives with various substituent groups were prepared and showed different absorption and fluorescence characteristics due to the substituent effect. On account of the existence of pyridine units, these TPA derivatives exhibited acid-induced tunable multicolor fluorescence emission including white light emission. In addition, acid-induced fluorescence regulation of these compounds has been also realized in the solid state, which enable them to be successfully constructed the stimuli-responsive fluorescent films and fluorescent inks for inkjet printing.
Delivery systems based on nanoparticles (NPs) have shown great potential to reduce side effects and improve the therapeutic efficacy. Herein, we report the one-pot synthesis of poly(ethylene glycol)-mediated zeolitic imidazolate framework-8 (ZIF-8) NPs for the co-delivery of an anticancer drug (i.e., doxorubicin) and a cell penetrating peptide containing histidine and arginine (i.e., H4R4) to improve the efficacy of therapeutic delivery. The cargo-encapsulated ZIF-8 NPs are pH-responsive, which are stable at neutral pH and degradable at acidic pH to release the encapsulated cargos. The released H4R4 can help for endosome/lysosome escape to enhance the cytotoxicity of the encapsulated drugs. In vivo studies demonstrate that the co-delivery of doxorubicin and H4R4 peptides can efficiently inhibit tumor growth without significant side effects. The reported strategy provides a new perspective on the design of drug delivery systems and brings more opportunities for biomedical applications.
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