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Outline
In view of the current situation of vague TCM syndrome classification standards for endometriosis (EMS) and the lack of data-driven research, this study aims to reveal the distribution pattern of TCM syndromes in EMS through multi-center large sample data, combined with cluster analysis and expert consensus as well as TCM theory, and to construct a dynamic syndrome classification model. Furthermore, it aims to provide evidence-based support for precise TCM diagnosis and treatment by integrating the new pathogenesis theory of “disorder of Chong meridian-blood stasis and vessel obstruction”.
A cross-sectional study design was adopted, and 714 EMS patients from 7 tertiary hospitals across the country were included. A 69-item syndrome questionnaire was optimized through the Delphi method. based on frequency analysis (frequency≥15%), 62 core symptoms were selected. K-means clustering algorithm (K=5 determined by the elbow method) was used for syndrome classification. Model stability was verified through Bootstrap resampling (1 000 times), and syndrome names and theoretical explanations were completed through expert consensus (consistency rate≥80%).
High-frequency symptoms included fatigue (56.16%), lumbar and knee weakness (51.40%), dysmenorrhea (50.00%), and cold pain in the lower abdomen (46.50%). Cluster analysis revealed five syndrome types: Cold aggregation and blood stasis syndrome (36.41%), qi Stagnation and blood stasis syndrome (22.69%), kidney deficiency and blood stasis syndrome (16.53%), qi deficiency and blood stasis syndrome (14.29%), and damp-heat and blood stasis syndrome (10.08%).
This study constructed a dynamic TCM syndrome classification model for EMS, with five representative syndromes including cold aggregation and blood stasis syndrome. Combined with the new pathogenesis theory of “disorder of Chong meridian-blood stasis and vessel obstruction”, it provides theoretical support for the standardized TCM diagnosis and accurate treatment of EMS.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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