To analyze the effect of Tianma Gegen decoction on ischemic stroke (Wind-Phlegm-Stasis Blocking Syndrome).

The clinical data of 105 patients with ischemic stroke (Wind-Phlegm-Stasis blocking syndrome) admitted to Rugao Hospital of Traditional Chinese Medicine during January 2021 to December 2023 were retrospectively analyzed. According to different treatment methods, they were divided into control group (n = 55, conventional treatment) and observation group (n = 50, conventional treatment + modified Tianma Gegen decoction). After 2 weeks of continuous treatment, the clinical efficacy, adverse reactions, and TCM symptom scores, degree of neurological impairment [National Institutes of Health Stroke Scale (NIHSS) score], serum indexes [neuron-specific enolase (NSE), matrix metalloproteinase (MMP)-9, intercellular adhesion molecule (ICAM)-1, monocyte chemoattractant protein(MCP)-1] levels before and after treatment were evaluated.

The total effective rate of observation group was 98.00%(49/50), which was higher than that of control group 85.45%(47/55) (P < 0.05). Compared with before treatment, TCM syndrome score, NIHSS score and serum levels of NSE, MMP-9, ICAM-1 and MCP-1 in both groups were decreased after treatment(P < 0.01), and the observation group was lower than the control group(P < 0.01). The total incidence of adverse reactions in observation group and control group was 8.00%(4/50) and 5.45%(3/55), respectively, with no statistical significance(P > 0.05).

The modified Tianma Gegen decoction in the treatment of ischemic stroke (Wind-Phlegm-Stasis Blocking Syndrome) can improve the therapeutic effect, alleviate symptoms, reduce the levels of serum NSE, MMP-9, ICAM-1 and MCP-1, which is conducive to the improvement of neurological impairment, and will not increase the occurrence of adverse reactions.