To explore the influence of combination of Formula No.2 for Heart Failure and acupoint application on myocardial enzymes and serum N-terminal pro-brain natriuretic peptide (NT-pro-BNP) and cardiac troponin T (cTnT) in patients with chronic heart failure (CHF).

Totally 120 patients with chronic heart failure were randomized in the Taizhou hospital from Dec. 2021 to December Dec. 2024 were randomly grouped. 60 cases in the control group were treated with conventional western medicine, and the remaining 60 cases in the treatment group were given combined therapy with Formula No.2 for heart failure and acupoint application on this basis. The clinical efficacy and TCM symptoms scores and levels of serum myocardial enzymes [lactate dehydrogenase (LDH), creatine kinase (CK), CK-MB, AST], NT-pro-BNP and cTnT before and after treatment were compared between groups, and the adverse reactions in both groups were observed.

The treatment group had higher total effective rate of treatment and lower scores of TCM symptoms after treatment compared to the control group (P < 0.05). The levels of LDH, CK, CK-MB, AST, NT-pro-BNP and cTnT in the treatment group were reduced after treatment compared with those in the control group (P < 0.05). No obvious differences were exhibited in the adverse reactions between both groups (P >0.05).

Formula No.2 for heart failure combined with acupoint application has a significant effect in the treatment of CHF, and it can effectively relieve the symptoms, and improve the myocardial enzymes and serum NT-pro-BNP and cTnT, without causing obvious adverse reactions.