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"Insomnia due to the kidney's failure to store the will" is a sub-type of insomnia within the TCM "Five-Spirit" diagnostic classification system for insomnia, characterized by the direct symptom of waking early after falling asleep at night. Its disease location is in the kidney, and the pathogenesis is the failure of the kidney-will to rest peacefully. The therapeutic method of calming the kidney will can be adopted for treatment. The medicinal herb Yuanzhi (Radix Polygalae), first documented in the Shennong Bencao Jing (Shennong's Collection of Materia Medica), was said to have the function of "strengthening the will and doubling strength". Subsequent physicians through the ages have extensively discussed it, believing that Yuanzhi has the function of "calming the kidney will". The herb pairs Yuanzhi-Fuling (or Fushen), Yuanzhi-Shudihuang, Yuanzhi-Yizhiren, Yuanzhi-Suanzaoren, and the compound formulas Huanshao pill, Kongsheng Zhenzhong pill, and Qifu decoction can all calm the kidney will to treat insomnia due to the kidney's failure to store the will. Among the herb pairs, Yuanzhi-Fuling (or Fushen) and Yuanzhi-Suanzaoren calm the heart spirit and soothe the kidney will; Yuanzhi-Shudihuang enriches kidney essence and nourishes kidney water to calm the kidney will; Yuanzhi-Yizhiren boosts intelligence, stabilizes qi, and calms the kidney will. Among the compound formulas, Huanshao pill tonifies the spleen and kidney, stabilizes the will, and calms the spirit; Kongsheng Zhenzhong pill tonifies the kidney and heart, calming the spirit and stabilizing the will; Qifu decoction tonifies the kidney and benefits the marrow, stabilizing the will and nourishing the spirit. Modern research indicates that the mechanism of Yuanzhi in treating this type of insomnia is related to improving neuroinflammation, oxidative stress, and regulating neurotransmitters, which can provide references for clinical and mechanistic research on Yuanzhi for this condition.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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