Objective: To observe the therapeutic effect of of Wang's Sanhe (lychee, hawthorn and mandarin orange seed) Formula in the treatment of kidney deficiency and stasis type prostatic hyperplasia and its effect on patients' bladder function.Methods: 120 patients with kidney deficiency and stasis type prostatic hyperplasia admitted to the Affiliated Hospital of Shanxi University of Traditional Chinese Medicine from January 2022 to June 2024 were selected and divided into two groups by lottery method. The conventional group was treated with tamsulosin hydrochloride capsule, and the Wang's Sanhe Formula group was combined with Wang's Sanhe Formula on the basis of the conventional group. Bladder function, prostate volume, 24h urination frequency, Chinese medicine symptom scores and changes in the levels of prostate - specific antigen (PSA), monocyte chemokine 1 (MCP - 1) and interleukin-8 (IL- 8) were compared before and after the treatment in the two groups, and adverse reactions were counted in the two groups.Results: Comparison of bladder function before treatment between the conventional group and Wang's Sanhe Formula group showed no statistically significant difference (P > 0.05). Maximum urinary flow rate (Qmax), average urinary flow rate (Qave) and effective bladder capacity were all higher after treatment in the conventional group and Wang's Sanhe Formula group than before treatment, and the differences in voiding time, urinary flow time and time to peak were not statistically significant when compared with those before treatment (P > 0.05). Qmax, Qave, and effective bladder capacity were higher in Wang's Sanhe Formula group after treatment than in the conventional group, and there was no statistically significant difference in voiding time, urine flow time, and time to peak compared with the conventional group (P > 0.05). Comparison of prostate volume, 24h urination frequency and TCM symptom scores before treatment between the conventional group and Wang's Sanhe Formula group, the difference was not statistically significant (P > 0.05). The prostate volume, 24 h urination frequency, and TCM symptom scores decreased after treatment in the conventional group and Wang's Sanhe Formula group compared with those before treatment, and the Wang's Sanhe Formula group was lower than the conventional group after treatment (P < 0.05). Comparison of serum PSA, MCP - 1 and IL - 8 before treatment between the conventional group and Wang's Sanhe Formula group showed no statistically significant difference (P >0.05). Serum PSA, MCP - 1, and IL - 8 decreased after treatment in both the conventional group and Wang's Sanhe Formula group compared with the pre - treatment period, and were lower in the Wang's Sanhe Formula group than in the conventional group after treatment (P < 0.05). Comparing the incidence of adverse reactions between the two groups (11.67% in the conventional group and 8.33% in the Wang's Sanhe Formula group), the difference was not statistically significant (P > 0.05).Conclusion: Wang's Sanhe Formula applied to kidney deficiency and stasis type prostatic hyperplasia can reduce the size of prostate, improve bladder function, reduce serum PSA, MCP - 1, IL - 8 levels and alleviate symptoms.

Wang's Sanhe Formula  /  Kidney deficiency and stasis type  /  Prostatic hyperplasia  /  Prostate volume  /  Bladder function