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Correlation Between Alzheimer′s Disease and Osteoporosis Based on ″Brain-Bone Axis″
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Qiuyan YE1, Xue LI1, Wei GAO2, Yutong ZHANG1, Miaomiao ZHANG1, Liping ZHENG1, Honglin LI1, 3
Acta Chinese Medicine | 2025, 40(12) : 2537 - 2542
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Acta Chinese Medicine | 2025, 40(12): 2537-2542
• Treatise •
Correlation Between Alzheimer′s Disease and Osteoporosis Based on ″Brain-Bone Axis″
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Qiuyan YE1, Xue LI1, Wei GAO2, Yutong ZHANG1, Miaomiao ZHANG1, Liping ZHENG1, Honglin LI1, 3
Affiliations
  • 1Heilongjiang University of Chinese Medicine, Harbin Heilongjiang China 150040
  • 2Jiangsu College of Nursing, Huai'an Jiangsu China 223003
  • 3The Second Affiliated Hospital to Heilongjiang University of Chinese Medicine, Harbin Heilongjiang China 150001
Published: 2025-12-10 doi: 10.16368/j.issn.1674-8999.2025.12.396
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Alzheimer's disease(AD)and osteoporosis(OP)are both related to the brain and correspond to the traditional Chinese medicine categories of″dementia″and″bone atrophy″,respectively.In traditional Chinese medicine,the brain is considered the sea of marrow,governing all the body's marrow.The brain marrow and bone marrow are interconnected;when the sea of marrow is abundant,the mind is vigorous,and the tendons and bones are strong and healthy.Insufficient marrow sea can lead to an inadequacy of brain marrow and bone marrow,potentially causing ″dementia″and ″osteoporosis″.Therefore,possible common pathogenic factors for AD and OP include β-amyloid deposition,estrogen deficiency,oxidative stress,vitamin deficiency,and APOE-ε4 gene expression.Exploring the correlation between AD and OP may broaden strategies for the prevention and treatment of both conditions.

Alzheimer's disease  /  osteoporosis  /  ″brain-bone axis″  /  brain marrow  /  bone marrow
叶秋燕, 李雪, 高伟, 张雨桐, 张苗苗, 郑利平, 李虹霖. 基于“脑-骨轴”探讨阿尔茨海默病与骨质疏松症的相关性. 中医学报, 2025 , 40 (12) : 2537 -2542 . DOI: 10.16368/j.issn.1674-8999.2025.12.396
Qiuyan YE, Xue LI, Wei GAO, Yutong ZHANG, Miaomiao ZHANG, Liping ZHENG, Honglin LI. Correlation Between Alzheimer′s Disease and Osteoporosis Based on ″Brain-Bone Axis″[J]. Acta Chinese Medicine, 2025 , 40 (12) : 2537 -2542 . DOI: 10.16368/j.issn.1674-8999.2025.12.396
Year 2025 volume 40 Issue 12
172
73
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doi: 10.16368/j.issn.1674-8999.2025.12.396
  • Receive Date:2025-06-12
  • Online Date:2026-10-10
  • Published:2025-12-10
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  • Received:2025-06-12
Affiliations
    1Heilongjiang University of Chinese Medicine, Harbin Heilongjiang China 150040
    2Jiangsu College of Nursing, Huai'an Jiangsu China 223003
    3The Second Affiliated Hospital to Heilongjiang University of Chinese Medicine, Harbin Heilongjiang China 150001
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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