Objective:To screen differentially expressed genes associated with cuproptosis in alcoholic liver cirrhosis using bioinformatics methods，explore their mechanisms of action，and identify traditional Chinese medicines with potential therapeutic effects.Methods:Datasets of patients with alcoholic liver cirrhosis meeting the criteria were selected from the GEO database.Differentially expressed genes（DEGs）were identified using software analysis，followed by KEGG pathway analysis and protein-protein interaction（PPI）network analysis to screen key genes.Random forest and SVMmodels，commonly used in machine learning，were applied to study the key genes. In addition，literature was reviewed to obtain cuproptosis-related genes（CRGs）.The DEGs and CRGs were intersected to identify core genes associated with cuproptosis，followed by GSEA enrichment analysis. Core genes retrieved from the Coremine database were used to predict therapeutic Chinese herbs.Results:By screening gene chips GSE167308 and GSE142530，278 DEGs were obtained.Through further selection via PPI and validation with GSE143318，10 key genes were identified.Literature review collected 38 CRGs，and the intersection yielded 2 cuproptosis core genes-CDKN2A（Cyclin-Dependent Kinase Inhibitor 2）and PLAT（Plasminogen Activator）.GSEA analysis indicated that the core genes are closely associated with linoleic acid metabolism，amino acid biosynthesis，arginine biosynthesis，HIF-1 signaling pathway，phenylalanine metabolism，and others. Chinese herbs such as Huci（Indian damnacanthus herb），Fengfang（Honeycomb），Diren（Melastoma dode candrum lour），Xiazhicao（Lagopsis supina），Hudilong（Lumbricus）and Qishe（Agkistrodon acutus）were identified through database search，and the attributes of the herbs including their four Qi，five Flavor，and meridian tropism were summarized. Conclusion:CDKN2A and PLAT are core genes related to cuproptosis in alcoholic cirrhosis.Prediction identified 35 Chinese herbs，which may serve as potential treatments for alcoholic cirrhosis.