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Outline
Objective:The purpose of this study is to analyze the medication patterns of Traditional Chinese Medicine（TCM）in the treatment of sarcopenia in the elderly using data mining，and to explore the mechanism of action of the core drug combination for sarcopenia through network pharmacology.Methods:A database was established using relevant literature sourced from Chinese and English databases such as CNKI，WanFang Data，VIP Journal Full-text Database and PubMed.The drug frequency and flavor meridian analysis were orgenized.Medication patterns were investigated based on frequency analysis，association rule analysis，cluster analysis，and complex network analysis.Network pharmacology was applied to elucidate the mechanism of action of the core drug combination in treating sarcopenia.Results:A total of 40 prescriptions involving 117 Chinese medicinal herbs with a cumulative frequency of 450 were included.The high-frequency drugs were respectively Baizhu（Atractylodes macrocephala），Gancao（Glycyrrhizae Radix），Fuling（Poria），Huangqi（Astragali Radix），Dangshen（Codonopsis Radix）.The majority of herbs were sweet and pungent in taste，warm and neutral in nature，and primarily associated with the Liver，Spleen，and Kidney meridians.Ten categories of herbs were involved.Association rule analysis revealed a high lift value between Baizhu（Atractylodes macrocephala）and Gancao（Glycyrrhizae Radix）. Cluster analysis categorized high-frequency herbs into three groups，and complex network analysis identified a core drug combination comprising Baizhu（Atractylodes macrocephala），Gancao（Glycyrrhizae Radix），Fuling（Poria），Dangshen（Codonopsis Radix），Chenpi（Pericarpium Citri Reticulatae）and Huangqi（Astragali Radix）.The core drug combination was found to involve 296 compounds and 118 potential targets in the treatment of sarcopenia in the elderly，with pathways such as adipocytokine signaling pathway，longevity regulating pathway，and insulin resistance being closely related.Molecular docking results showed that key active compounds like Vitamin D3，Emodin，and Calycosin had high binding activity with critical target proteins. Conclusion:The clinical use of TCMfor sarcopenia in the elderly focuses on the Spleen as the core，emphasizing the simultaneous replenishment of qi and blood，as well as the harmonization of liver and kidney functions，while also attending to blood circulation and removing blood stasis.The core drug combination may ameliorate sarcopenia through regulating lipid metabolism and inflammation-related pathways via multiple pathways and targets.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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