Multimorbidity（referred to as comorbidity）has become an increasingly prominent global public health challenge，and the traditional single-disease diagnosis and treatment model struggles to address its complexity.Traditional Chinese Medicine（TCM），with its holistic concept，syndrome differentiation-based treatment，and preventive treatment theories，demonstrates unique advantages in the prevention and management of comorbidity.This article systematically reviews the evolution of the concept of comorbidity，the current status of western medical diagnosis and treatment，and the problems it faces，such as unclear mechanisms，diagnostic difficulties，limited interventions，polypharmacy，and a lack of assessment tools，and proposes research strategies for TCM in addressing comorbidity.The discussion focuses on key aspects including the core pathogenesis and syndrome characteristics of comorbidity，the establishment of syndrome diagnostic criteria，individualized intervention strategies，the development of tools for efficacy and prognosis evaluation，emphasizing the research ideas of″combining disease pattern and syndrome pattern″and″guiding disease treatment with syndromes″.The aim is to provide theoretical foundations and methodological support for clinical research on comorbidity in TCM.