Full
Outline
Multidrug resistance（MDR）in tumors is a key reason for the failure of clinical chemotherapy and severely limits the expected efficacy of chemotherapeutic drugs.Traditional Chinese medicine（TCM）has a clear therapeutic value in reversing drug resistance，manifested in reducing resistance proteins，inhibiting mutant genes，and enhancing cellular sensitivity.The treatment of chemotherapy resistance in lung cancer can be approached based on the four pathological factors of″Phlegm，″″blood stasis，″″Toxin″，and ″deficiency.″At the microscopic level，Chinese medicine formulas and extracts can effectively regulate resistance proteins such as P-glycoprotein（P-gp），multidrug resistance-associated protein（MRP），and lung resistance-associated protein（LRP）；specific enzymes such as GST-π，ToPoⅡ，PKC；and the expression levels of apoptosis-related genes Bax，Bcl-2，and p53，thereby exerting therapeutic effects in reversing chemotherapy resistance.Future basic research on TCMin reversing drug resistance may focus on the ″classical pathway″，″non-classical pathway″，and ″apoptotic pathway″，designing resistance proteins，specific enzymes，and apoptosis genes as research targets，which could form a more comprehensive efficacy evaluation system. By exploring related signaling pathways along these three pathways，potential mechanisms for reversing drug resistance may be identified，aiming to reveal the objective molecular biological mechanisms of tumor multidrug resistance（MDR）.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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