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Design and Simulation of Cryoablation Needle with Adjustable Throttle-Nozzle
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Chi Yang1, 2, Tao Song3, Zhaohua Chang1, 2, Baolin Liu1
Journal of Refrigeration | 2025, 46(4) : 149 - 155
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Journal of Refrigeration | 2025, 46(4): 149-155
Design and Simulation of Cryoablation Needle with Adjustable Throttle-Nozzle
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Chi Yang1, 2, Tao Song3, Zhaohua Chang1, 2, Baolin Liu1
Affiliations
  • 1.Institute of Biothermal Technology, University of Shanghai for Science and Technology, Shanghai, 200093, China
  • 2.AccuTarget MediPharma (Shanghai) Co., Ltd., Shanghai, 200120, China
  • 3.Shanghai Jian Qiao University, Shanghai, 201306, China
Published: 2025-08-16 doi: 10.12465/j.issn.0253-4339.2025.04.149
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In tumor cryoablation therapy, the effective improvement of the cooling rate of the freezing process is a research hotspot. In this study, a novel cryoablation needle with an adjustable throttle nozzle was designed. The external surface temperature of the needle could be reduced to -80 ℃ within just 4 s, while the traditional cryoablation needle with a fixed throttling nozzle requires 73 s. The three-dimensional heat transfer model simulation results show that the temperature around the cryoablation needle drops sharply to -150 ℃ within 120 s, and the fastest instantaneous cooling rate is 1 500-1 575 ℃/min, which achieves the purpose of rapid cooling. In addition, the -20 ℃ isotherm has a small variation range from 60 s to 120 s (increasing from 5 mm to 6.5 mm), and the temperature changes tend to be gentle after 120 s, and the tissue damage range increases to 9 mm, indicating that the tissue damage range increases significantly. Comprehensive studies have shown that the adjustable throttling nozzle cryoablation needle has a higher cooling rate and larger effective ablation range, which is of great significance for clinical cryoablation treatment.

tumor  /  cryoablation  /  cooling rate  /  bio-heat transfer model
Chi Yang, Tao Song, Zhaohua Chang, Baolin Liu. Design and Simulation of Cryoablation Needle with Adjustable Throttle-Nozzle[J]. Journal of Refrigeration, 2025 , 46 (4) : 149 -155 . DOI: 10.12465/j.issn.0253-4339.2025.04.149
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Article Info
doi: 10.12465/j.issn.0253-4339.2025.04.149
  • Receive Date：2024-04-08
  • Online Date：2026-03-13
  • Published：2025-08-16
Article Data
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History
  • Received：2024-04-08
  • Revised：2024-05-13
  • Accepted：2024-06-11
Affiliations
    1.Institute of Biothermal Technology, University of Shanghai for Science and Technology, Shanghai, 200093, China
    2.AccuTarget MediPharma (Shanghai) Co., Ltd., Shanghai, 200120, China
    3.Shanghai Jian Qiao University, Shanghai, 201306, China

Corresponding:

Liu Baolin, male, professor, Institute of Biothermal Technology, University of Shanghai for Science and Technology, 86-21-55277768, E-mail: . Research fields: cryo-biomedical engineering.
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表12种不同金属材料的力学参数
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Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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